Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing.
Animals
Apoptosis
/ drug effects
Inflammation
/ chemically induced
Lipopolysaccharides
/ pharmacology
Macrophages
/ drug effects
Male
Mice
NADPH Oxidase 2
/ metabolism
NF-kappa B
/ metabolism
Peritonitis
/ chemically induced
Reactive Oxygen Species
/ metabolism
Signal Transduction
/ drug effects
Sodium-Phosphate Cotransporter Proteins, Type III
/ metabolism
Thioglycolates
/ toxicity
Transcription Factor Pit-1
/ genetics
Tumor Necrosis Factor-alpha
/ metabolism
Wound Healing
/ drug effects
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 02 2019
12 02 2019
Historique:
received:
02
05
2018
accepted:
27
11
2018
entrez:
14
2
2019
pubmed:
14
2
2019
medline:
1
9
2020
Statut:
epublish
Résumé
PiT1/SLC20A1 is an inorganic phosphate transporter with additional functions including the regulation of TNFα-induced apoptosis, erythropoiesis, cell proliferation and insulin signaling. Recent data suggest a relationship between PiT1 and NF-κB-dependent inflammation: (i) Pit1 mRNA is up-regulated in the context of NF-κB pathway activation; (ii) NF-κB target gene transcription is decreased in PiT1-deficient conditions. This led us to investigate the role of PiT1 in lipopolysaccharide (LPS)-induced inflammation. MCP-1 and IL-6 concentrations were impaired in PiT1-deficient bone marrow derived macrophages (BMDMs) upon LPS stimulation. Lower MCP-1 and IL-6 serum levels were observed in Mx1-Cre; Pit1
Identifiants
pubmed: 30755642
doi: 10.1038/s41598-018-37551-1
pii: 10.1038/s41598-018-37551-1
pmc: PMC6372663
doi:
Substances chimiques
Lipopolysaccharides
0
NF-kappa B
0
Pit1 protein, mouse
0
Reactive Oxygen Species
0
Slc20a1 protein, mouse
0
Sodium-Phosphate Cotransporter Proteins, Type III
0
Thioglycolates
0
Transcription Factor Pit-1
0
Tumor Necrosis Factor-alpha
0
NADPH Oxidase 2
EC 1.6.3.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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