Distinct Subsets of Lateral Hypothalamic Neurotensin Neurons are Activated by Leptin or Dehydration.
Animal Feed
Animals
Brain
/ drug effects
Colchicine
/ pharmacology
Dehydration
/ metabolism
Feeding Behavior
Female
Genotype
Green Fluorescent Proteins
/ metabolism
Hypothalamic Area, Lateral
/ metabolism
Leptin
/ metabolism
Male
Mesencephalon
/ drug effects
Mice
Mice, Inbred C57BL
Neurons
/ metabolism
Neurotensin
/ metabolism
Neurotransmitter Agents
Water
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 02 2019
12 02 2019
Historique:
received:
08
06
2018
accepted:
20
12
2018
entrez:
14
2
2019
pubmed:
14
2
2019
medline:
24
9
2020
Statut:
epublish
Résumé
The lateral hypothalamic area (LHA) is essential for ingestive behavior but it remains unclear how LHA neurons coordinate feeding vs. drinking. Most LHA populations promote food and water consumption but LHA neurotensin (Nts) neurons preferentially induce water intake while suppressing feeding. We identified two molecularly and projection-specified subpopulations of LHA Nts neurons that are positioned to coordinate either feeding or drinking. One subpopulation co-expresses the long form of the leptin receptor (LepRb) and is activated by the anorectic hormone leptin (Nts
Identifiants
pubmed: 30755658
doi: 10.1038/s41598-018-38143-9
pii: 10.1038/s41598-018-38143-9
pmc: PMC6372669
doi:
Substances chimiques
Leptin
0
Neurotransmitter Agents
0
Water
059QF0KO0R
Green Fluorescent Proteins
147336-22-9
Neurotensin
39379-15-2
Colchicine
SML2Y3J35T
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1873Subventions
Organisme : NIEHS NIH HHS
ID : T32 ES007255
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103808
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS)
ID : T32-ES00725527
Pays : International
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK107081
Pays : United States
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