The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy.
Journal
Nature reviews. Cancer
ISSN: 1474-1768
Titre abrégé: Nat Rev Cancer
Pays: England
ID NLM: 101124168
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
pubmed:
14
2
2019
medline:
21
5
2019
entrez:
14
2
2019
Statut:
ppublish
Résumé
Checkpoint inhibitor-based immunotherapies that target cytotoxic T lymphocyte antigen 4 (CTLA4) or the programmed cell death 1 (PD1) pathway have achieved impressive success in the treatment of different cancer types. Yet, only a subset of patients derive clinical benefit. It is thus critical to understand the determinants driving response, resistance and adverse effects. In this Review, we discuss recent work demonstrating that immune checkpoint inhibitor efficacy is affected by a combination of factors involving tumour genomics, host germline genetics, PD1 ligand 1 (PDL1) levels and other features of the tumour microenvironment, as well as the gut microbiome. We focus on recently identified molecular and cellular determinants of response. A better understanding of how these variables cooperate to affect tumour-host interactions is needed to optimize the implementation of precision immunotherapy.
Identifiants
pubmed: 30755690
doi: 10.1038/s41568-019-0116-x
pii: 10.1038/s41568-019-0116-x
pmc: PMC6705396
mid: NIHMS1043064
doi:
Substances chimiques
B7-H1 Antigen
0
CTLA-4 Antigen
0
Immunologic Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
133-150Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA205426
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA160001
Pays : United States
Organisme : NIH HHS
ID : P30 CA008748
Pays : United States
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