Non-invasive structure-function assessment of the liver by 2D time-harmonic elastography and the dynamic Liver MAximum capacity (LiMAx) test.
Acetamides
/ administration & dosage
Adult
Aged
Aged, 80 and over
Aspartate Aminotransferases
/ blood
Carbon Isotopes
/ administration & dosage
Case-Control Studies
Disease Progression
Elasticity Imaging Techniques
Female
Hepatectomy
Humans
Liver
/ diagnostic imaging
Liver Cirrhosis
/ blood
Liver Function Tests
Male
Middle Aged
Platelet Count
Predictive Value of Tests
Reproducibility of Results
Severity of Illness Index
Young Adult
LiMAx
dynamic liver function test
liver fibrosis
liver stiffness
time-harmonic elastography
ultrasound elastography
Journal
Journal of gastroenterology and hepatology
ISSN: 1440-1746
Titre abrégé: J Gastroenterol Hepatol
Pays: Australia
ID NLM: 8607909
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
17
12
2018
revised:
23
01
2019
accepted:
10
02
2019
pubmed:
14
2
2019
medline:
3
3
2020
entrez:
14
2
2019
Statut:
ppublish
Résumé
Accurate assessment of structural and functional characteristics of the liver could improve the diagnosis and the clinical management of patients with chronic liver diseases. However, the structure-function relationship in the progression of chronic liver disease remains elusive. The aim of this study is the combined measurement of liver function by the LiMAx test and time-harmonic elastography were applied, and the serological scores fibrosis 4 index and aspartate aminotransferase to platelet ratio index were calculated in patients with chronic liver diseases (n = 75) and healthy control subjects (n = 22). In 47 patients who underwent surgery, fibrosis was graded by histological examination of the resected liver tissue. LiMAx values correlated negatively with liver stiffness (r = -0.747), aminotransferase to platelet ratio index (r = -0.604), and fibrosis 4 (r = -0.573). Median (interquartile range) LiMAx values decreased with fibrosis progression from 395 μg/kg/h (371-460 μg/kg/h) in participants with no fibrosis to 173 μg/kg/h (126-309 μg/kg/h) in patients with severe fibrosis. Median liver stiffness increased progressively with the stage of fibrosis from no fibrosis (1.56 m/s [1.52-1.63 m/s]) to moderate fibrosis (1.60 m/s [1.54-1.67 m/s]) to severe fibrosis (1.85 m/s [1.76-1.92 m/s]). Our findings show that structural changes in the liver due to progressing liver diseases and reflected by increased tissue stiffness correlate with a functional decline of the organ as reflected by a decreased metabolic capacity of the liver.
Sections du résumé
BACKGROUND AND AIM
OBJECTIVE
Accurate assessment of structural and functional characteristics of the liver could improve the diagnosis and the clinical management of patients with chronic liver diseases. However, the structure-function relationship in the progression of chronic liver disease remains elusive. The aim of this study is the combined measurement of liver function by the
METHODS
METHODS
LiMAx test and time-harmonic elastography were applied, and the serological scores fibrosis 4 index and aspartate aminotransferase to platelet ratio index were calculated in patients with chronic liver diseases (n = 75) and healthy control subjects (n = 22). In 47 patients who underwent surgery, fibrosis was graded by histological examination of the resected liver tissue.
RESULTS
RESULTS
LiMAx values correlated negatively with liver stiffness (r = -0.747), aminotransferase to platelet ratio index (r = -0.604), and fibrosis 4 (r = -0.573). Median (interquartile range) LiMAx values decreased with fibrosis progression from 395 μg/kg/h (371-460 μg/kg/h) in participants with no fibrosis to 173 μg/kg/h (126-309 μg/kg/h) in patients with severe fibrosis. Median liver stiffness increased progressively with the stage of fibrosis from no fibrosis (1.56 m/s [1.52-1.63 m/s]) to moderate fibrosis (1.60 m/s [1.54-1.67 m/s]) to severe fibrosis (1.85 m/s [1.76-1.92 m/s]).
CONCLUSION
CONCLUSIONS
Our findings show that structural changes in the liver due to progressing liver diseases and reflected by increased tissue stiffness correlate with a functional decline of the organ as reflected by a decreased metabolic capacity of the liver.
Substances chimiques
Acetamides
0
Carbon Isotopes
0
methacetin
13E468TFHP
Aspartate Aminotransferases
EC 2.6.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1611-1619Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : LiSyM, grant number 031L0057
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK2260 BIOQIC
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1340 Matrix-in-Vision
Organisme : German Research Foundation
ID : SFB1340
Organisme : German Research Foundation
ID : BIOQIC
Organisme : German Research Foundation
ID : GRK2260
Organisme : Federal Ministry of Education and Research
ID : 031 L0057
Informations de copyright
© 2019 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
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