Chiral separation of rasagiline using sulfobutylether-β-cyclodextrin: capillary electrophoresis, NMR and molecular modeling study.
Azilect®
Chiral separation
Cyclodextrin
Enantioseparation
Migration order
Journal
Electrophoresis
ISSN: 1522-2683
Titre abrégé: Electrophoresis
Pays: Germany
ID NLM: 8204476
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
15
11
2018
revised:
11
02
2019
accepted:
11
02
2019
pubmed:
14
2
2019
medline:
12
2
2020
entrez:
14
2
2019
Statut:
ppublish
Résumé
Pressure-assisted stereospecific capillary electrophoresis method was developed for the determination of enantiomeric purity of the antiparkinsonian agent (R)-rasagiline. The optimized method, 50 mM glycine-HCl buffer pH 2, supplied with 30 mM sulfobutylether-β-cyclodextrin, at 35°C, applying 12 kV in reversed polarity, and -8 mbar pressure (vacuum), short-end injection with -25 mbar × 2 s, was successful for baseline separation of rasagiline enantiomers (R
Identifiants
pubmed: 30758065
doi: 10.1002/elps.201800482
doi:
Substances chimiques
Indans
0
beta-Cyclodextrins
0
rasagiline
003N66TS6T
SBE4-beta-cyclodextrin
2PP9364507
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1897-1903Informations de copyright
© 2019 The Authors. Electrophoresis published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.