Structural and functional connectivity in newly diagnosed juvenile myoclonic epilepsy.


Journal

Acta neurologica Scandinavica
ISSN: 1600-0404
Titre abrégé: Acta Neurol Scand
Pays: Denmark
ID NLM: 0370336

Informations de publication

Date de publication:
May 2019
Historique:
received: 03 01 2019
accepted: 10 02 2019
pubmed: 14 2 2019
medline: 24 5 2019
entrez: 14 2 2019
Statut: ppublish

Résumé

We aimed to evaluate structural and functional connectivity of patients with newly diagnosed juvenile myoclonic epilepsy (JME) compared to healthy subjects. We enrolled 36 patients with a diagnosis of JME, who were newly diagnosed and drug-naïve. They underwent T1-weighted imaging, and structural volumes were calculated using FreeSurfer software. In addition, EEG data were obtained from all of them. Structural and functional connectivity matrices were estimated by calculating the structural volumes and EEG amplitude correlation, respectively. Then, the connectivity measures were calculated using the BRAPH program. We also enrolled healthy subjects to compare its structural and functional connectivity with the patients with JME. We observed that patients with JME exhibited significantly different functional and structural connectivity compared to healthy control subjects. In the global structural connectivity, global efficiency, and local efficiency, and small-worldness index were decreased, whereas characteristic path length was increased in patients with JME. Betweenness centrality of cingulate, precentral, superior parietal, and superior frontal cortex was increased in patients with JME whereas that of hippocampus was decreased. In the functional connectivity, the betweenness centrality of the fronto-central electrodes was significantly increased. This study reports that the structural connectivity and functional connectivity in patients with JME are significantly different from those in healthy control subjects, even those with newly diagnosed drug-naive state. The patients with JME exhibited disrupted topological disorganization of the global brain network and hub reorganization in structural and functional connectivity. These alterations are implicated in the pathogenesis of JME and suggestive of network disease.

Identifiants

pubmed: 30758836
doi: 10.1111/ane.13079
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

469-475

Subventions

Organisme : Inje University

Informations de copyright

© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Auteurs

Ho-Joon Lee (HJ)

Department of Radiology, Haeundae Paik Hospital, Busan, Korea.

Kang Min Park (KM)

Department of Neurology, Haeundae Paik Hospital, Busan, Korea.

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Classifications MeSH