A Recurrent Motif: Diversity and Evolution of ShKT Domain Containing Proteins in the Vampire Snail
Astacin
CRISP
Gastropoda
ShKT
domain duplication
gene duplication
haematophagy
parasitism
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
12 02 2019
12 02 2019
Historique:
received:
14
01
2019
revised:
04
02
2019
accepted:
07
02
2019
entrez:
15
2
2019
pubmed:
15
2
2019
medline:
31
12
2019
Statut:
epublish
Résumé
Proteins of the ShK superfamily are characterized by a small conserved domain (ShKT), first discovered in small venom peptides produced by sea anemones, and acting as specific inhibitors of voltage-dependent and calcium-activated K⁺ channels. The ShK superfamily includes both small toxic peptides and larger multifunctional proteins with various functions. ShK toxins are often important components of animal venoms, where they perform different biological functions including neurotoxic and immunosuppressive effects. Given their high specificity and effectiveness, they are currently regarded as promising pharmacological lead compounds for the treatment of autoimmune diseases. Here, we report on the molecular analysis of ShKT domain containing proteins produced by the Mediterranean vampire snail
Identifiants
pubmed: 30759797
pii: toxins11020106
doi: 10.3390/toxins11020106
pmc: PMC6409789
pii:
doi:
Substances chimiques
Cnidarian Venoms
0
Potassium Channel Blockers
0
ShK neurotoxin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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