Chemistry, Alpha-glucosidase and Radical Scavenging Properties of Uranyl(VI) Hydrazide Complexes.
DPPH
hydrazide
nitric oxide
superoxide
uranyl(VI)
α-glucosidase.
Journal
Medicinal chemistry (Shariqah (United Arab Emirates))
ISSN: 1875-6638
Titre abrégé: Med Chem
Pays: Netherlands
ID NLM: 101240303
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
11
2018
revised:
15
01
2019
accepted:
28
01
2019
pubmed:
15
2
2019
medline:
4
12
2019
entrez:
15
2
2019
Statut:
ppublish
Résumé
Antioxidant, anti-inflammatory, antiviral and antitumoral activities among others are essential characteristics in the development of novel therapeutic compounds. Acid hydrazides can form complexation with certain metal ions that positively enhance these biological characteristics. Five new complexes of uranium with hydrazide ligands were synthesized at room temperature. The characterization was done by spectroscopic methods (ESI-Mass, IR, 1H-NMR, 13CNMR), CHN analysis and conductivity measurements. Metal complexes along with their respective ligands were further screened for their antioxidant (DPPH, superoxide and nitric oxide free radicals) properties and enzyme inhibition (α-glucosidase) activities. Elemental and spectral data indicate octahedral geometry around uranyl (UO2 2+) species. Magnetic moments indicate the diamagnetic nature of uranyl(VI) ion in the complex in solid state. IC50 values showed potential antioxidant behavior of uranyl complexes demonstrating interesting structure-activity relationships. In general, hydrazide ligands were not active against superoxide and nitric oxide radicals while varying degree of results were observed against DPPH radical whereas all uranyl-complexes showed promising radical scavenging activities against all of them. Promising inhibitory potential was displayed by UO2 +2 hydrazide complexes against α- glucosidases whereas free hydrazide ligands were inactive. Structure function relationship demonstrates that the nature of ligand, position of substituent, electronic and steric effects are significant factors affecting the radical scavenging and enzyme inhibition activities of the compounds.
Sections du résumé
BACKGROUND
BACKGROUND
Antioxidant, anti-inflammatory, antiviral and antitumoral activities among others are essential characteristics in the development of novel therapeutic compounds. Acid hydrazides can form complexation with certain metal ions that positively enhance these biological characteristics.
OBJECTIVE
OBJECTIVE
Five new complexes of uranium with hydrazide ligands were synthesized at room temperature.
METHODS
METHODS
The characterization was done by spectroscopic methods (ESI-Mass, IR, 1H-NMR, 13CNMR), CHN analysis and conductivity measurements. Metal complexes along with their respective ligands were further screened for their antioxidant (DPPH, superoxide and nitric oxide free radicals) properties and enzyme inhibition (α-glucosidase) activities.
RESULTS
RESULTS
Elemental and spectral data indicate octahedral geometry around uranyl (UO2 2+) species. Magnetic moments indicate the diamagnetic nature of uranyl(VI) ion in the complex in solid state. IC50 values showed potential antioxidant behavior of uranyl complexes demonstrating interesting structure-activity relationships. In general, hydrazide ligands were not active against superoxide and nitric oxide radicals while varying degree of results were observed against DPPH radical whereas all uranyl-complexes showed promising radical scavenging activities against all of them. Promising inhibitory potential was displayed by UO2 +2 hydrazide complexes against α- glucosidases whereas free hydrazide ligands were inactive.
CONCLUSION
CONCLUSIONS
Structure function relationship demonstrates that the nature of ligand, position of substituent, electronic and steric effects are significant factors affecting the radical scavenging and enzyme inhibition activities of the compounds.
Identifiants
pubmed: 30760191
pii: MC-EPUB-96615
doi: 10.2174/1573406415666190213101044
doi:
Substances chimiques
Biphenyl Compounds
0
Coordination Complexes
0
Free Radical Scavengers
0
Glycoside Hydrolase Inhibitors
0
Hydrazines
0
Picrates
0
Nitric Oxide
31C4KY9ESH
Uranium
4OC371KSTK
1,1-diphenyl-2-picrylhydrazyl
DFD3H4VGDH
alpha-Glucosidases
EC 3.2.1.20
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
923-936Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.