IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.

Animals Ataxia Telangiectasia Mutated Proteins / metabolism Brain Neoplasms / genetics Cell Differentiation DNA Damage / genetics DNA Methylation / genetics DNA Repair / genetics Disease Models, Animal Epigenesis, Genetic Gene Ontology Genome Glioma / genetics Histones / metabolism Humans Isocitrate Dehydrogenase / genetics Mice Mutation / genetics Oligodendroglia / pathology Radiation Tolerance Signal Transduction Survival Analysis Tumor Suppressor Proteins / genetics Up-Regulation / genetics

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
13 02 2019
Historique:
received: 05 10 2017
revised: 08 08 2018
accepted: 28 12 2018
entrez: 15 2 2019
pubmed: 15 2 2019
medline: 23 2 2020
Statut: ppublish

Résumé

Patients with glioma whose tumors carry a mutation in isocitrate dehydrogenase 1 (IDH1

Identifiants

DOI: 10.1126/scitranslmed.aaq1427 PMID: 30760578 PMC: PMC6400220
pubmed: 30760578
pii: 11/479/eaaq1427
doi: 10.1126/scitranslmed.aaq1427
pmc: PMC6400220
mid: NIHMS1011707
pii:
doi:

Substances chimiques

Histones 0
Tumor Suppressor Proteins 0
Isocitrate Dehydrogenase EC 1.1.1.41
Idh1 protein, mouse EC 1.1.1.42
IDH1 protein, human EC 1.1.1.42.
Ataxia Telangiectasia Mutated Proteins EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NINDS NIH HHS
ID : K08 NS099427
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA224160
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105556
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008602
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS082311
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG047200
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA169316
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA158286
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG006786
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS103500
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS076991
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS094804
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK097153
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS096756
Pays : United States
Organisme : NINDS NIH HHS
ID : K08 NS110919
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA151022
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA181475
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009110
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100864
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS106554
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB022563
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM086262
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009676
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA172380
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG027237
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES017885
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126947
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS106887
Pays : United States
Organisme : NCI NIH HHS
ID : L30 CA188846
Pays : United States

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Références

J Immunol Methods. 2009 Aug 15;347(1-2):70-8
pubmed: 19567251
Genes Dev. 2017 Apr 15;31(8):774-786
pubmed: 28465358
Glia. 2017 Dec;65(12):1914-1926
pubmed: 28836293
Science. 2013 Mar 29;339(6127):1546-58
pubmed: 23539594
Cell. 2016 Jan 28;164(3):550-63
pubmed: 26824661
DNA Repair (Amst). 2015 Dec;36:2-7
pubmed: 26507443
Sci Transl Med. 2017 Feb 1;9(375):
pubmed: 28148839
Int J Radiat Oncol Biol Phys. 2002 Feb 1;52(2):316-24
pubmed: 11872276
N Engl J Med. 2009 Feb 19;360(8):765-73
pubmed: 19228619
Science. 2014 Jan 10;343(6167):189-193
pubmed: 24336570
Cancer Res. 2009 Jan 15;69(2):431-9
pubmed: 19147555
Cancer Metab. 2018 Apr 17;6:4
pubmed: 29692895
N Engl J Med. 2016 Apr 7;374(14):1344-55
pubmed: 27050206
Science. 2008 Sep 26;321(5897):1807-12
pubmed: 18772396
Radiother Oncol. 2015 Sep;116(3):381-7
pubmed: 26328938
Stem Cells Dev. 2011 Feb;20(2):363-74
pubmed: 20491544
Cell. 2017 Feb 9;168(4):644-656
pubmed: 28187286
Bioinformatics. 2017 Aug 1;33(15):2381-2383
pubmed: 28369316
Neuro Oncol. 2012 Feb;14(2):132-44
pubmed: 22067563
Neuro Oncol. 2017 Feb 1;19(2):242-251
pubmed: 27571885
N Engl J Med. 2012 Mar 22;366(12):1079-89
pubmed: 22417203
Nature. 2009 Dec 10;462(7274):739-44
pubmed: 19935646
Nature. 2009 Oct 22;461(7267):1071-8
pubmed: 19847258
Am J Pathol. 2009 Apr;174(4):1149-53
pubmed: 19246647
Neuro Oncol. 2013 Jan;15(1):57-68
pubmed: 23115158
Genes Dev. 1996 Oct 1;10(19):2411-22
pubmed: 8843194
Science. 2013 May 3;340(6132):626-30
pubmed: 23558169
J Vis Exp. 2010 Sep 08;(43):
pubmed: 20864925
Cancer Cell. 2010 Dec 14;18(6):553-67
pubmed: 21130701
J Neurooncol. 2016 Apr;127(2):363-72
pubmed: 26780338
Nat Biotechnol. 2009 Dec;27(12):1181-5
pubmed: 19935656
Cancer Res. 2015 Nov 15;75(22):4790-802
pubmed: 26363012
Cancer Res. 2002 Jul 15;62(14):4142-50
pubmed: 12124353
Cancer Discov. 2016 May;6(5):532-45
pubmed: 27001151
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nature. 2012 Feb 15;483(7390):479-83
pubmed: 22343889
Cancer Cell. 2011 Jan 18;19(1):17-30
pubmed: 21251613
Science. 2011 Jul 22;333(6041):425
pubmed: 21719641
Methods. 2014 May 1;67(1):45-54
pubmed: 23973811
Cancer Cell. 2016 Aug 8;30(2):337-348
pubmed: 27424808
Transl Oncol. 2009 May;2(2):89-95
pubmed: 19412424
J Clin Oncol. 2010 Aug 1;28(22):3636-43
pubmed: 20567020
Bioinformatics. 2014 Sep 1;30(17):i393-400
pubmed: 25161225
Clin Cancer Res. 2014 Jun 1;20(11):2898-909
pubmed: 24714777
N Engl J Med. 2015 Jun 25;372(26):2481-98
pubmed: 26061751
Nature. 2012 Feb 15;483(7390):474-8
pubmed: 22343901
Sci Transl Med. 2016 Mar 2;8(328):328ra28
pubmed: 26936505

Auteurs

Felipe J Núñez (FJ)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
ORCID: 0000-0002-4962-3642

Flor M Mendez (FM)

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Padma Kadiyala (P)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Mahmoud S Alghamri (MS)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
ORCID: 0000-0002-8018-7674

Masha G Savelieff (MG)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
ORCID: 0000-0001-5575-2494

Maria B Garcia-Fabiani (MB)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Santiago Haase (S)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Carl Koschmann (C)

Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Anda-Alexandra Calinescu (AA)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
ORCID: 0000-0002-7641-1573

Neha Kamran (N)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Meghna Saxena (M)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Rohin Patel (R)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Stephen Carney (S)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
ORCID: 0000-0001-7786-5158

Marissa Z Guo (MZ)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Marta Edwards (M)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Mats Ljungman (M)

Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Environmental Health Science, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
ORCID: 0000-0003-1553-6695

Tingting Qin (T)

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.

Maureen A Sartor (MA)

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.

Rebecca Tagett (R)

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
ORCID: 0000-0001-8604-7683

Sriram Venneti (S)

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
ORCID: 0000-0001-9764-0423

Jacqueline Brosnan-Cashman (J)

Departments of Pathology, Oncology and Urology, Johns Hopkins University, Baltimore, MD 21287, USA.
ORCID: 0000-0001-9579-2853

Alan Meeker (A)

Departments of Pathology, Oncology and Urology, Johns Hopkins University, Baltimore, MD 21287, USA.

Vera Gorbunova (V)

Department of Biology, University of Rochester, Rochester, NY 14627, USA.
ORCID: 0000-0001-8979-0333

Lili Zhao (L)

Department of Biostatistics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Daniel M Kremer (DM)

Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Graduate Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

Li Zhang (L)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
ORCID: 0000-0002-0703-7506

Costas A Lyssiotis (CA)

Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA.
ORCID: 0000-0001-9309-6141

Lindsey Jones (L)

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
ORCID: 0000-0001-9603-7366

Cameron J Herting (CJ)

Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30322, USA.
Graduate Division of Molecular and Systems Pharmacology, Emory University, Atlanta, GA 30322, USA.

James L Ross (JL)

Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30322, USA.
Graduate Division of Cancer Biology, Emory University, Atlanta, GA 30322, USA.

Dolores Hambardzumyan (D)

Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30322, USA.

Shawn Hervey-Jumper (S)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Maria E Figueroa (ME)

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136-1000, USA.

Pedro R Lowenstein (PR)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA. mariacas@med.umich.edu pedrol@med.umich.edu.
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
ORCID: 0000-0002-8427-4409

Maria G Castro (MG)

Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA. mariacas@med.umich.edu pedrol@med.umich.edu.
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
ORCID: 0000-0002-4962-3642

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Protéines mutées dans l'ataxie-télangiectasie › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Vocabulaire contrôlé › Ontologies biologiques › Gene Ontology › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Isocitrate dehydrogenases › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Cellules › Névroglie › Oligodendroglie › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Phénomènes physiologiques › Radiotolérance › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › IDH1-R132H acts as a tumor suppressor in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › IDH1-R132H acts as a tumor suppressor in...