Periostin plays role in force-induced stem cell potential by periodontal ligament stem cells.
POSTN
compressive force
periodontal ligament
stem cells
Journal
Cell biology international
ISSN: 1095-8355
Titre abrégé: Cell Biol Int
Pays: England
ID NLM: 9307129
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
21
08
2018
accepted:
10
02
2019
pubmed:
15
2
2019
medline:
10
9
2019
entrez:
15
2
2019
Statut:
ppublish
Résumé
Mechanical stimuli have been shown to play an important role in directing stem cell fate and maintenance of tissue homeostasis. One of the functions of the mechanoresponsive tissue periodontal ligament (PDL) is to withstand the functional forces within the oral cavity. Periodontal ligament stem cells (PDLSCs) derived from periodontal tissue have been demonstrated to be able to respond directly to mechanical forces. However, the mechanisms of action of mechanical force on PDLSCs are not totally understood. The aim of this study was to investigate the mechanisms by which compressive force affects PDLSCs, especially their stemness properties. PDLSCs were established from extracted human third molars; their stem cell characteristics were validated by detecting the expression of stem cell markers and confirming their ability to differentiate into osteogenic and adipogenic lineages. PDLSCs were subjected to various magnitudes of static compressive force (0 [control], 0.5, 1.0, 1.5, or 2 g/cm
Substances chimiques
Biomarkers
0
Cell Adhesion Molecules
0
POSTN protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
506-515Subventions
Organisme : Prince of Songkla University
Informations de copyright
© 2019 International Federation for Cell Biology.