Axonal water fraction as marker of white matter injury in primary-progressive multiple sclerosis: a longitudinal study.
Adult
Axons
/ pathology
Biomarkers
Brain
/ diagnostic imaging
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
/ methods
Disease Progression
Female
Humans
Longitudinal Studies
Male
Middle Aged
Multiple Sclerosis, Chronic Progressive
/ diagnostic imaging
Netherlands
Water
White Matter
/ diagnostic imaging
magnetic resonance imaging
axonal water fraction
diffusion kurtosis imaging
disease progression
primary-progressive multiple sclerosis
Journal
European journal of neurology
ISSN: 1468-1331
Titre abrégé: Eur J Neurol
Pays: England
ID NLM: 9506311
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
07
10
2018
accepted:
05
02
2019
pubmed:
15
2
2019
medline:
8
8
2020
entrez:
15
2
2019
Statut:
ppublish
Résumé
Diffuse white matter (WM) injury is prominent in primary-progressive multiple sclerosis (PP-MS) pathology and is a potential biomarker of disease progression. Diffusion kurtosis imaging allows the quantification of non-Gaussian water diffusion, providing metrics with high WM pathological specificity. The aim of this study was to characterize the pathological changes occurring in the normal-appearing WM of patients with PP-MS at baseline and at 1-year follow-up and to assess their impact on disability and short-term disease progression. A total of 26 patients with PP-MS and 20 healthy controls were prospectively enrolled. Diffusion kurtosis imaging single-shot echo-planar imaging (EPI) was acquired on a 3-T scanner (Philips Achieva, Best, The Netherlands) (voxel size, 2 × 2 × 2 mm At baseline, patients with PP-MS showed a widespread decrease of AWF, tortuosity and D Based on its change over time and its relationship with disease progression, among the analyzed metrics, AWF seems the most sensitive metric of WM tissue damage in PP-MS and therefore it could be considered as a marker for monitoring disease progression.
Sections du résumé
BACKGROUND AND PURPOSE
Diffuse white matter (WM) injury is prominent in primary-progressive multiple sclerosis (PP-MS) pathology and is a potential biomarker of disease progression. Diffusion kurtosis imaging allows the quantification of non-Gaussian water diffusion, providing metrics with high WM pathological specificity. The aim of this study was to characterize the pathological changes occurring in the normal-appearing WM of patients with PP-MS at baseline and at 1-year follow-up and to assess their impact on disability and short-term disease progression.
METHODS
A total of 26 patients with PP-MS and 20 healthy controls were prospectively enrolled. Diffusion kurtosis imaging single-shot echo-planar imaging (EPI) was acquired on a 3-T scanner (Philips Achieva, Best, The Netherlands) (voxel size, 2 × 2 × 2 mm
RESULTS
At baseline, patients with PP-MS showed a widespread decrease of AWF, tortuosity and D
CONCLUSION
Based on its change over time and its relationship with disease progression, among the analyzed metrics, AWF seems the most sensitive metric of WM tissue damage in PP-MS and therefore it could be considered as a marker for monitoring disease progression.
Substances chimiques
Biomarkers
0
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1068-1074Informations de copyright
© 2019 EAN.