Heterochromatin anomalies and double-stranded RNA accumulation underlie
Amyotrophic Lateral Sclerosis
/ genetics
Animals
Brain
/ metabolism
C9orf72 Protein
/ genetics
Chromobox Protein Homolog 5
Chromosomal Proteins, Non-Histone
/ metabolism
Dipeptides
/ genetics
Disease Models, Animal
Green Fluorescent Proteins
HEK293 Cells
Heterochromatin
/ pathology
Humans
Mice
Mice, Inbred C57BL
Nuclear Lamina
/ pathology
RNA, Double-Stranded
/ metabolism
Repetitive Sequences, Nucleic Acid
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
02
09
2018
revised:
07
12
2018
accepted:
14
01
2019
entrez:
16
2
2019
pubmed:
16
2
2019
medline:
2
8
2019
Statut:
ppublish
Résumé
How hexanucleotide GGGGCC (G
Identifiants
pubmed: 30765536
pii: 363/6428/eaav2606
doi: 10.1126/science.aav2606
pmc: PMC6524780
mid: NIHMS1020267
pii:
doi:
Substances chimiques
C9orf72 Protein
0
C9orf72 protein, human
0
CBX5 protein, human
0
Chromosomal Proteins, Non-Histone
0
Dipeptides
0
Heterochromatin
0
RNA, Double-Stranded
0
Chromobox Protein Homolog 5
107283-02-3
Green Fluorescent Proteins
147336-22-9
prolylarginine
2418-74-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Subventions
Organisme : NINDS NIH HHS
ID : R35 NS097273
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG057528
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS063964
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS088689
Pays : United States
Organisme : NIGMS NIH HHS
ID : DP2 GM119139
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS084974
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS099114
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS100717
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062359
Pays : United States
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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