Impacts of post-transplantation cyclophosphamide treatment after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia.
Adult
Cyclophosphamide
/ metabolism
Cyclosporine
/ therapeutic use
Female
Graft vs Host Disease
/ drug therapy
Hematopoietic Stem Cell Transplantation
/ methods
Hematopoietic Stem Cells
/ metabolism
Humans
Immunosuppressive Agents
/ therapeutic use
Leukemia, Myeloid, Acute
/ drug therapy
Male
Middle Aged
Retrospective Studies
Transplantation Conditioning
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 02 2019
14 02 2019
Historique:
received:
05
10
2018
accepted:
20
12
2018
entrez:
16
2
2019
pubmed:
16
2
2019
medline:
30
9
2020
Statut:
epublish
Résumé
Post-transplant cyclophosphamide has become a promising medical option after allogeneic HSCT. In this study we aimed to evaluate the efficacy of cyclophosphamide and cyclosporine combination in acute and chronic graft-versus-host disease (GvHD) prophylaxis in acute myeloid leukemia (AML) cases scheduled for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Retrospective analysis of data from 40 cases who underwent allogeneic HSCT under GvHD prophylaxis with cyclophosphamide and cyclosporine combination between April 2016 and August 2017 was made. Cyclophosphamide was given at daily doses of 50 mg/kg on post-transplant 3
Identifiants
pubmed: 30765830
doi: 10.1038/s41598-019-38644-1
pii: 10.1038/s41598-019-38644-1
pmc: PMC6376163
doi:
Substances chimiques
Immunosuppressive Agents
0
Cyclosporine
83HN0GTJ6D
Cyclophosphamide
8N3DW7272P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2046Références
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