Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Study #575B.
Adolescent
Adult
Aged
Aged, 80 and over
Algorithms
Case-Control Studies
Female
Genetic Predisposition to Disease
/ genetics
Genomics
Humans
Interviews as Topic
Male
Middle Aged
Polymorphism, Single Nucleotide
/ genetics
Psychiatric Status Rating Scales
Stress Disorders, Post-Traumatic
/ genetics
Surveys and Questionnaires
United States
United States Department of Veterans Affairs
/ statistics & numerical data
Veterans
/ psychology
Young Adult
Clinician-Administered PTSD Scale
combat-exposed veterans
genomics
medical record review
posttraumatic stress disorder (PTSD)
Journal
International journal of methods in psychiatric research
ISSN: 1557-0657
Titre abrégé: Int J Methods Psychiatr Res
Pays: United States
ID NLM: 9111433
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
12
06
2018
revised:
13
09
2018
accepted:
07
11
2018
pubmed:
16
2
2019
medline:
16
1
2020
entrez:
16
2
2019
Statut:
ppublish
Résumé
Heritability in the risk for developing posttraumatic stress disorder (PTSD) has been established, but most genome-wide association studies (GWASs) of PTSD involve relatively small sample sizes and limited identification of associated genetic loci. This report describes the methodology of a Veterans Affairs (VA) Cooperative Studies Program GWAS of PTSD among combat-exposed U.S. veterans. Probable cases (with PTSD) and probable controls (without PTSD) were identified from among veterans enrolled in the VA Million Veteran Program (MVP) with an algorithm developed using questionnaire responses and electronic health record information. This algorithm, based on a statistical model, relied on medical chart reviews as a reference standard and was refined using telephone interviews. Subsequently, to evaluate the impact of probabilistic phenotyping on statistical power, the threshold probability for case-control selection was varied in simulations. As of September 2018, >695,000 veterans have enrolled in MVP. For current analyses, genotyping data were available for >353,000 participants, including >83,000 combat-exposed veterans. A threshold probability of 0.7 for case and control designation yielded an interim >16,000 cases and >33,000 controls. A formal methodological approach was used to identify cases and controls for subsequent GWAS analyses to identify genetic risk loci for PTSD.
Identifiants
pubmed: 30767326
doi: 10.1002/mpr.1767
pmc: PMC6877159
doi:
Banques de données
ClinicalTrials.gov
['NCT02256644']
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1767Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2019 John Wiley & Sons, Ltd.
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