Activity of ceftolozane/tazobactam against Pseudomonas aeruginosa and Enterobacterales isolates recovered from intensive care unit patients in Spain: The SUPERIOR multicentre study.
Anti-Bacterial Agents
/ pharmacology
Aspartate Aminotransferases
/ blood
Cephalosporins
/ pharmacology
Enterobacteriaceae
/ drug effects
Enterobacteriaceae Infections
/ microbiology
Humans
Intensive Care Units
Intraabdominal Infections
/ microbiology
Microbial Sensitivity Tests
Prospective Studies
Pseudomonas Infections
/ microbiology
Pseudomonas aeruginosa
/ drug effects
Spain
Tazobactam
/ pharmacology
Urinary Tract Infections
/ microbiology
beta-Lactamase Inhibitors
/ pharmacology
Ceftolozane/tazobactam
Intensive care unit
Intra-abdominal infection
Spain
Urinary tract infection
Journal
International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
23
10
2018
revised:
23
01
2019
accepted:
06
02
2019
pubmed:
16
2
2019
medline:
9
8
2019
entrez:
16
2
2019
Statut:
ppublish
Résumé
Patients in intensive care units (ICUs) present a high risk of developing an infection caused by multidrug-resistant bacteria. Consequently, new antimicrobials and combinations are required. In this study, the activity of ceftolozane/tazobactam (C/T) was evaluated against Enterobacterales (n = 400) and Pseudomonas aeruginosa (n = 80) clinical isolates collected from patients in Spanish ICUs with complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI). Overall susceptibility to C/T in P. aeruginosa isolates by infection type was 95.7% in cUTI (MIC
Identifiants
pubmed: 30769199
pii: S0924-8579(19)30027-5
doi: 10.1016/j.ijantimicag.2019.02.004
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Cephalosporins
0
beta-Lactamase Inhibitors
0
ceftolozane, tazobactam drug combination
0
Aspartate Aminotransferases
EC 2.6.1.1
Tazobactam
SE10G96M8W
Types de publication
Journal Article
Multicenter Study
Langues
eng
Pagination
682-688Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.