Pivotal role for α
ECM
LLPC
T follicular helper
germinal center
integrin
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
05 03 2019
05 03 2019
Historique:
pubmed:
17
2
2019
medline:
9
4
2020
entrez:
17
2
2019
Statut:
ppublish
Résumé
CD4+ follicular helper T cells (Tfh) are essential for germinal center (GC) reactions in the lymph node that generate high-affinity, long-lived plasma cells (LLPCs). Temporal GC analysis suggests B memory cells (Bmem) are generated early, while LLPCs are generated late in the GC reaction. Distinct roles for Tfh at these temporally different stages are not yet clear. Tfh entry into the GC is highly dynamic and the signals that maintain Tfh within the GC for support of late LLPC production are poorly understood. The GC is marked by inflammation-induced presentation of specific ECM components. To determine if T cell recognition of these ECM components played a role in Tfh support of the GC, we immunized mice with a T cell-restricted deletion of the ECM-binding integrin α
Identifiants
pubmed: 30770452
pii: 1809329116
doi: 10.1073/pnas.1809329116
pmc: PMC6410787
doi:
Substances chimiques
Integrin alphaV
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4462-4470Subventions
Organisme : NIAID NIH HHS
ID : R01 AI136536
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007285
Pays : United States
Organisme : NIDCR NIH HHS
ID : T90 DE021985
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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