Understanding skin absorption of common aldehyde vapours from exposure during hazardous material incidents.
Aldehydes
Dermal exposure
HAZMAT
In vitro
Vapour
Journal
Journal of exposure science & environmental epidemiology
ISSN: 1559-064X
Titre abrégé: J Expo Sci Environ Epidemiol
Pays: United States
ID NLM: 101262796
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
18
06
2018
accepted:
16
11
2018
revised:
29
10
2018
pubmed:
17
2
2019
medline:
15
12
2020
entrez:
17
2
2019
Statut:
ppublish
Résumé
The toxic release of aldehyde vapours during a hazardous material (HAZMAT) incident primarily results in respiratory concerns for the unprotected public. However, skin absorption may be an important concurrent exposure route that is poorly understood for this scenario. This study provides experimental data on the skin absorption properties of common aldehydes used in industry, including acetaldehyde, acrolein, benzaldehyde and formaldehyde, in gaseous or vapour form using an adapted in vitro technique. Two of the four tested aldehydes were found to penetrate the skin in appreciable amounts following 30-min exposure at HAZMAT relevant atmospheric concentrations: acetaldehyde (5.29 ± 3.24 µg/cm
Identifiants
pubmed: 30770841
doi: 10.1038/s41370-019-0127-4
pii: 10.1038/s41370-019-0127-4
doi:
Substances chimiques
Aldehydes
0
Hazardous Substances
0
Formaldehyde
1HG84L3525
Acetaldehyde
GO1N1ZPR3B
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
537-546Références
Gaskin S, Heath L, Pisaniello D, Evans R, Edwards JW, Logan M, et al. Hydrogen sulphide and phosphine interactions with human skin in vitro: application to hazardous material incident decision making for skin decontamination. Toxicol Ind Health. 2017;33:289–96.
doi: 10.1177/0748233716630646
Levitin HW, Siegelson HJ, Dickinson S, Halpern P, Haraguchi Y, Nocera A, et al. Decontamination of mass casualties—re-evaluating existing dogma. Prehosp Disaster Med. 2003;18:200–7.
doi: 10.1017/S1049023X00001060
Gaskin S, Heath L, Pisaniello D, Edwards JW, Logan M, Baxter C. Dermal absorption of fumigant gases during HAZMAT incident exposure scenarios—ethyl bromide, sulfuryl fluoride, and chloropicrin. Toxicol Ind Health. 2017;33:547–54.
doi: 10.1177/0748233716689651
Chilcott RP. Managing mass casualties and decontamination. Environ Int. 2014;72:37–45.
doi: 10.1016/j.envint.2014.02.006
Kuykendall JR. 8.16—aldehydes A2. In: McQueen CA, editor. Comprehensive toxicology. 2nd ed. Oxford: Elsevier; 2010. p. 291–330. https://doi.org/10.1016/B978-0-08-046884-6.00916-7 .
Occupational Safety and Health Administration. Fatality and Catastrophe Investigation Summaries Dataset. obtained from Occupational Safety and Health Administration Fatality and Catastrophe Investigation Summaries, Washington; 2018. https://www.osha.gov/pls/imis/accidentsearch.html .
National Oceanic and Atmospheric Administration. Incidents dataset obtained from National Oceanic and Atmospheric Administration IncidentNews Database; 2018. https://incidentnews.noaa.gov/search/date .
Brandt-Rauf PW, Fallon LF, Tarantini T, Idema C, Andrews L. Health hazards of fire fighters: exposure assessment. Br J Ind Med. 1988;45:606.
pubmed: 3179235
pmcid: 1009663
Bolstad-Johnson DM, Burgess JL, Crutchfield CD, Storment S, Gerkin R, Wilson JR. Characterization of firefighter exposures during fire overhaul. AIHA J. 2000;61:636–41.
doi: 10.1202/0002-8894(2000)061<0636:COFEDF>2.0.CO;2
Caux C, O’Brien C, Viau C. Determination of firefighter exposure to polycyclic aromatic hydrocarbons and benzene during fire fighting using measurement of biological indicators. Appl Occup Environ Hyg. 2002;17:379–86.
doi: 10.1080/10473220252864987
Fent KW, Eisenberg J, Snawder J, Sammons D, Pleil JD, Stiegel MA, et al. Systemic exposure to PAHs and benzene in firefighters suppressing controlled structure fires. Ann Occup Hyg. 2014;58:830–45.
pubmed: 24906357
pmcid: 4124999
Edelman P, Osterloh J, Pirkle J, Caudill SP, Grainger J, Jones R, et al. Biomonitoring of chemical exposure among New York City firefighters responding to the World Trade Center fire and collapse. Environ Health Perspect. 2003;111:1906–11.
doi: 10.1289/ehp.6315
Dellarco VL. A mutagenicity assessment of acetaldehyde. Mutat Res Rev Genet Toxicol. 1988;195:1–20.
doi: 10.1016/0165-1110(88)90013-9
Sithu SD, Srivastava S, Siddiqui MA, Vladykovskaya E, Riggs DW, Conklin DJ, et al. Exposure to acrolein by inhalation causes platelet activation. Toxicol Appl Pharmacol. 2010;248:100–10.
doi: 10.1016/j.taap.2010.07.013
Final report on the safety assessment of benzaldehyde 1. Int J Toxicol. 2006;25:11–27.
Kim K-H, Jahan SA, Lee J-T. Exposure to formaldehyde and its potential human health hazards. J Environ Sci Health Part C. 2011;29:277–99.
doi: 10.1080/10590501.2011.629972
Gomes R, Liteplo RG, Meek ME. Acrolein: hazard characterization and exposure–response analysis. J Environ Sci Health, Part C. 2001;19:23–43.
doi: 10.1081/GNC-100103579
Lacroix M, Burckel H, Foussereau J, Grosshans E, Cavelier C, Limasset JC, et al. Irritant dermatitis from diallylglycol carbonate monomer in the optical industry. Contact Dermat. 1976;2:183–95.
doi: 10.1111/j.1600-0536.1976.tb03025.x
Faroon O, Roney N, Taylor J, Ashizawa A, Lumpkin M, Plewak D. Acrolein health effects. Toxicol Ind Health. 2008;24:447–90.
doi: 10.1177/0748233708094188
Lodén M. The in vitro permeability of human skin to benzene, ethylene glycol, formaldehyde, and n-hexane. Acta Pharmacol Toxicol. 1986;58:382–9.
doi: 10.1111/j.1600-0773.1986.tb00126.x
Hafeez F, Chiang A, Hui X, Maibach H. Role of partition coefficients in determining the percutaneous penetration of salicylic acid and formaldehyde under varying occlusion durations. Drug Dev Ind Pharm. 2014;40:1395–401.
doi: 10.3109/03639045.2013.828218
Stotts J, Ely WJ. Induction of human skin sensitization to ethanol. J Invest Dermatol. 1977;69:219–22.
doi: 10.1111/1523-1747.ep12506333
Wilkin JK, Fortner G. Ethnic contact urticaria to alcohol. Contact Dermat. 1985;12:118–20.
doi: 10.1111/j.1600-0536.1985.tb01073.x
Sato A, Obata K, Ikeda K, Ohkoshi K, Okumura H, Ozawa N, et al. Evaluation of human skin irritation by carboxylic acids, alcohols, esters and aldehydes, with nitrocellulose-replica method and closed patch testing. Contact Dermat. 1996;34:12–6.
doi: 10.1111/j.1600-0536.1996.tb02104.x
Haddock NF, Wilkin JK. Cutaneous reactions to lower aliphatic alcohols before and during disulfiram therapy. Arch Dermatol. 1982;118:157–9.
doi: 10.1001/archderm.1982.01650150019013
Barry BW, Harrison SM, Dugard PH. Vapour and liquid diffusion of model penetrants through human skin; correlation with thermodynamic activity. J Pharm Pharmacol. 1985;37:226–36.
doi: 10.1111/j.2042-7158.1985.tb05050.x
Gaskin S, Pisaniello D, Edwards JW, Bromwich D, Reed S, Logan M, et al. In-vitro methods for testing dermal absorption and penetration of toxic gases. Toxicol Mech Methods. 2014;24:70–2.
doi: 10.3109/15376516.2013.859193
Heath L, Gaskin S, Pisaniello D, Crea J, Logan M, Baxter C. Skin absorption of ethylene oxide gas following exposures relevant to HAZMAT incidents. Ann Work Expo Health. 2017;61:589–95.
doi: 10.1093/annweh/wxx030
Lawrence JN. Electrical resistance and tritiated water permeability as indicators of barrier integrity of in vitro human skin. Toxicol Vitr. 1997;11:241–9.
doi: 10.1016/S0887-2333(97)00015-5
Diembeck W, Beck H, Benech-Kieffer F, Courtellemont P, Dupuis J, Lovell W, et al. Test guidelines for in vitro assessment of dermal absorption and percutaneous penetration of cosmetic ingredients. Food Chem Toxicol. 1999;37:191–205.
doi: 10.1016/S0278-6915(98)00114-8
Davies DJ, Ward RJ, Heylings JR. Multi-species assessment of electrical resistance as a skin integrity marker for in vitro percutaneous absorption studies. Toxicol Vitr. 2004;18:351–8.
doi: 10.1016/j.tiv.2003.10.004
Pisaniello D. The generation of test atmospheres for occupational hygiene laboratory evaluation of organic vapour monitoring devices report prepared for the Occupational Health and Radiation Control Branch, Occupational Health and Radiation Control Branch, South Australian Health Commission, Adelaide; 1988.
Frasch FHA. Random walk model of skin permeation. Risk Anal. 2002;22:265–76.
doi: 10.1111/0272-4332.00024
Barry BW, Harrison SM, Dugard PH. Correlation of thermodynamic activity and vapour diffusion through human skin for the model compound, benzyl alcohol. J Pharm Pharmacol. 1985;37:84–90.
doi: 10.1111/j.2042-7158.1985.tb05012.x
Driver J, Ross J, Mihlan G, Lunchick C, Landenberger B. Derivation of single layer clothing penetration factors from the pesticide handlers exposure database. Regul Toxicol Pharmacol. 2007;49:125–37.
doi: 10.1016/j.yrtph.2007.06.007
Chao K-P, Wang P, Chen C-P, Tang P-Y. Assessment of skin exposure to N,N-dimethylformamide and methyl ethylketone through chemical protective gloves and decontamination of gloves for reuse purposes. Sci Total Environ. 2011;409:1024–32.
doi: 10.1016/j.scitotenv.2010.11.034
Berthet A, Hopf NB, Miles A, Spring P, Charrière N, Garrigou A, et al. Human skin in vitro permeation of bentazon and isoproturon formulations with or without protective clothing suit. Arch Toxicol. 2014;88:77–88.
doi: 10.1007/s00204-013-1087-4
Protano C, Guidotti M, Vitali M. Performance of different work clothing types for reducing skin exposure to pesticides during open field treatment. Bull Environ Contam Toxicol. 2009;83:115–9.
doi: 10.1007/s00128-009-9753-1
Dickson EFG. Estimates of percutaneous toxicity of sulfur mustard vapor suitable for use in protective equipment standards. J Toxicol Environ Health Part A. 2008;71:1382–91.
doi: 10.1080/15287390802271616
Heck HD, Casanova-Schmitz M, Dodd PB, Schachter EN, Witek TJ, Tosun T. Formaldehyde (CH
doi: 10.1080/15298668591394275
Casanova M, d’A. Heck H, Everitt JI, Harrington WW, Popp JA. Formaldehyde concentrations in the blood of rhesus monkeys after inhalation exposure. Food Chem Toxicol. 1988;26:715–6.
doi: 10.1016/0278-6915(88)90071-3
European Food Safety Authority. Endogenous formaldehyde turnover in humans compared with exogenous contribution from food sources. EFSA J. 2014;12:3550.