Maternal preeclampsia and respiratory outcomes in extremely premature infants.
Adult
Angiogenesis Inhibitors
/ pharmacology
Bronchopulmonary Dysplasia
/ diagnosis
Female
Gestational Age
Humans
Infant, Extremely Premature
Infant, Newborn
Infant, Premature, Diseases
Male
Mothers
Neovascularization, Pathologic
Pre-Eclampsia
/ diagnosis
Pregnancy
Prospective Studies
Regression Analysis
Respiratory Distress Syndrome, Newborn
/ diagnosis
Risk Factors
Journal
Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
06
08
2018
accepted:
31
01
2019
revised:
28
01
2019
pubmed:
17
2
2019
medline:
13
5
2020
entrez:
17
2
2019
Statut:
ppublish
Résumé
Preeclampsia (PE) is a pregnancy complication characterized by an anti-angiogenic environment. This can affect fetal pulmonary vascular and alveolar development but data of the impact of PE on respiratory outcome in extremely premature infants are inconclusive. The objective of this study was to determine if PE is associated with an increased risk for severe respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in extremely premature infants. Prospectively collected single center data from a cohort of infants born at 23-28 w gestational age between January 2005 and December 2015 were analyzed. Logistic regression analysis and generalized estimating equations were used to model the association between PE and severe RDS (≥30% supplemental oxygen on d1), BPD and severe BPD [supplemental oxygen and ≥30% oxygen at 36 w postmenstrual age (PMA), respectively]. The cohort included 1218 infants of whom 23% were exposed to PE. PE was associated with increased risk for severe RDS as well as severe BPD among infants alive at 36w PMA. Exposure to preeclampsia is independently associated with an increased risk for severe RDS and adverse respiratory outcome in extreme premature infants. The mechanisms behind these associations need to be investigated.
Sections du résumé
BACKGROUND
Preeclampsia (PE) is a pregnancy complication characterized by an anti-angiogenic environment. This can affect fetal pulmonary vascular and alveolar development but data of the impact of PE on respiratory outcome in extremely premature infants are inconclusive. The objective of this study was to determine if PE is associated with an increased risk for severe respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in extremely premature infants.
METHODS
Prospectively collected single center data from a cohort of infants born at 23-28 w gestational age between January 2005 and December 2015 were analyzed. Logistic regression analysis and generalized estimating equations were used to model the association between PE and severe RDS (≥30% supplemental oxygen on d1), BPD and severe BPD [supplemental oxygen and ≥30% oxygen at 36 w postmenstrual age (PMA), respectively].
RESULTS
The cohort included 1218 infants of whom 23% were exposed to PE. PE was associated with increased risk for severe RDS as well as severe BPD among infants alive at 36w PMA.
CONCLUSION
Exposure to preeclampsia is independently associated with an increased risk for severe RDS and adverse respiratory outcome in extreme premature infants. The mechanisms behind these associations need to be investigated.
Identifiants
pubmed: 30770862
doi: 10.1038/s41390-019-0336-5
pii: 10.1038/s41390-019-0336-5
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM