Regulation of the pleiotropic effects of tissue-resident mast cells.
Animals
Calcium
/ immunology
Chemotaxis
/ immunology
Humans
Interleukin-4
/ immunology
Intestinal Mucosa
/ immunology
Lysosomes
/ immunology
Mast Cells
/ immunology
Phagocytosis
Proto-Oncogene Proteins c-kit
/ immunology
Receptors, IgE
/ immunology
Respiratory Mucosa
/ immunology
Signal Transduction
/ immunology
FcεRI
IL-4
Toll-like receptors
calcium signaling
chemotaxis
chymase
integrins
ion channels
phosphatases
stem cell factor
tryptase
Journal
The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
13
04
2018
revised:
29
01
2019
accepted:
01
02
2019
pubmed:
18
2
2019
medline:
11
6
2020
entrez:
18
2
2019
Statut:
ppublish
Résumé
Mast cells (MCs), which are best known for their detrimental role in patients with allergic diseases, act in a diverse array of physiologic and pathologic functions made possible by the plurality of MC types. Their various developmental avenues and distinct sensitivity to (micro-) environmental conditions convey extensive heterogeneity, resulting in diverse functions. We briefly summarize this heterogeneity, elaborate on molecular determinants that allow MCs to communicate with their environment to fulfill their tasks, discuss the protease repertoire stored in secretory lysosomes, and consider different aspects of MC signaling. Furthermore, we describe key MC governance mechanisms (ie, the high-affinity receptor for IgE [FcεRI]), the stem cell factor receptor KIT, the IL-4 system, and both Ca
Identifiants
pubmed: 30772496
pii: S0091-6749(19)30207-6
doi: 10.1016/j.jaci.2019.02.004
pii:
doi:
Substances chimiques
IL4 protein, human
0
Receptors, IgE
0
Interleukin-4
207137-56-2
KIT protein, human
EC 2.7.10.1
Proto-Oncogene Proteins c-kit
EC 2.7.10.1
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
S31-S45Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.