Clinical course of neuromyelitis optica spectrum disorder in a moroccan cohort.
Morocco
Neuromyelitis optica spectrum disorder
Transverse myelitis
antiaquaporine 4 antibodies
autoimmune disorders
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
16
12
2018
revised:
01
02
2019
accepted:
05
02
2019
pubmed:
18
2
2019
medline:
10
8
2019
entrez:
18
2
2019
Statut:
ppublish
Résumé
Neuromyelitis optica spectrum disorder (NMOSD) was suggested to be more frequent and have specific features among populations from Africa or North Africa. However, we could not find any large study about NMOSD in an African population in the medical literature. To describe the characteristics of NMOSD in a Moroccan monocenter population. A retrospective study was conducted. Patients fromJanuary 1999 to December 2015 fulfilling the 2015 International Consensus Criteria for NMOSD were included. Sixty four patients fulfilled the criteria. Mean age at onset was 35.7 ± 10.7 years, and the sex ratio was 1/3.57. First clinical event was represented by optic neuritis (38.1%), followed by myelitis (27.0%) and a Devic's syndrome (17.2%). Mean annualized relapse rate was 1.07 ± 1.23 and mean EDSS at last visit was 5.1 ± 2.8. Aquaporine 4 antibodies were positive in 47.1%. Brain lesions were found in 71.2%. Most patients (76.6%) received disease-modifying therapy, mainly cyclophosphamide (86.0%) and 49% remained relapse-free after treatment initiation CONCLUSION: Data from our study suggest more similarities between North African NMOSD patients and non-Caucasian populations. More studies are needed to assess other pathological patterns and compare disease course to other populations.
Sections du résumé
BACKGROUND
BACKGROUND
Neuromyelitis optica spectrum disorder (NMOSD) was suggested to be more frequent and have specific features among populations from Africa or North Africa. However, we could not find any large study about NMOSD in an African population in the medical literature.
OBJECTIVES
OBJECTIVE
To describe the characteristics of NMOSD in a Moroccan monocenter population.
PATIENTS AND METHODS
METHODS
A retrospective study was conducted. Patients fromJanuary 1999 to December 2015 fulfilling the 2015 International Consensus Criteria for NMOSD were included.
RESULTS
RESULTS
Sixty four patients fulfilled the criteria. Mean age at onset was 35.7 ± 10.7 years, and the sex ratio was 1/3.57. First clinical event was represented by optic neuritis (38.1%), followed by myelitis (27.0%) and a Devic's syndrome (17.2%). Mean annualized relapse rate was 1.07 ± 1.23 and mean EDSS at last visit was 5.1 ± 2.8. Aquaporine 4 antibodies were positive in 47.1%. Brain lesions were found in 71.2%. Most patients (76.6%) received disease-modifying therapy, mainly cyclophosphamide (86.0%) and 49% remained relapse-free after treatment initiation CONCLUSION: Data from our study suggest more similarities between North African NMOSD patients and non-Caucasian populations. More studies are needed to assess other pathological patterns and compare disease course to other populations.
Identifiants
pubmed: 30772672
pii: S2211-0348(19)30068-9
doi: 10.1016/j.msard.2019.02.012
pii:
doi:
Substances chimiques
AQP4 protein, human
0
Aquaporin 4
0
Autoantibodies
0
Types de publication
Journal Article
Langues
eng
Pagination
141-148Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.