In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model.
aneurysm healing
embolization device
polyurethane foam
shape memory polymer
Journal
Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
Titre abrégé: J Biomed Mater Res B Appl Biomater
Pays: United States
ID NLM: 101234238
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
02
11
2018
revised:
17
01
2019
accepted:
26
01
2019
pubmed:
19
2
2019
medline:
4
9
2020
entrez:
19
2
2019
Statut:
ppublish
Résumé
Shape memory polymer (SMP) foam-coated coils (FCCs) are new embolic coils coated with porous SMP designed to expand for increased volume filling and enhanced healing after implantation. The purpose of this study was to compare chronic aneurysm healing after treatment with SMP FCCs to bare platinum coil (BPC) controls in the rabbit elastase aneurysm model. BPCs or SMP FCCs were implanted in rabbit elastase-induced aneurysms for follow-up at 30 days (n = 10), 90 days (n = 5), and 180 days (n = 12 for BPCs; n = 14 for SMP FCCs). Aneurysm occlusion and histologic healing, including a qualitative healing score, neointima thickness, collagen deposition, and inflammation were compared between the two groups. The mean neointima thickness was significantly greater in groups treated with SMP FCCs for all three time points. Histologic healing scores and collagen deposition quantification suggested that aneurysms treated with SMP FCCs experience more complete healing of the dome by 90 days, but the differences were not statistically significant. More progressive occlusion and recanalization were observed in aneurysms treated with SMP FCCs, but neither difference was statistically significant. Additionally, the SMP foam used in the FCCs was found to degrade faster in the rabbit elastase model than expected based on previous studies in a porcine sidewall aneurysm model. This study suggests that SMP FCCs can promote neointima formation along the aneurysm neck, and may lead to more complete healing of the dome and neck. These findings indicate potential benefits of this device for aneurysm occlusion procedures. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2466-2475, 2019.
Identifiants
pubmed: 30775843
doi: 10.1002/jbm.b.34337
pmc: PMC7384583
mid: NIHMS1607967
doi:
Substances chimiques
Coated Materials, Biocompatible
0
Smart Materials
0
Pancreatic Elastase
EC 3.4.21.36
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2466-2475Subventions
Organisme : NINDS NIH HHS
ID : U01 NS089692
Pays : United States
Organisme : U.S. Department of Defense
Pays : International
Organisme : NINDS NIH HHS
ID : U01-NS089692
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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