Impaired behavioural flexibility related to white matter microgliosis in the TgAPP21 rat model of Alzheimer disease.
Alzheimer Disease
/ metabolism
Amyloid beta-Protein Precursor
/ genetics
Animals
Brain
/ metabolism
Cognition
/ physiology
Conditioning, Operant
/ physiology
Disease Models, Animal
Executive Function
/ physiology
Male
Maze Learning
/ physiology
Microglia
/ metabolism
Neuroimmunomodulation
/ physiology
Plaque, Amyloid
/ pathology
Rats
Rats, Inbred F344
Rats, Transgenic
White Matter
/ metabolism
Alzheimer disease
Amyloid precursor protein
Behavioral flexibility
Executive function
Microglia
Neuroinflammation
Regressive error
Reversal
White matter
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
19
09
2018
revised:
11
02
2019
accepted:
14
02
2019
pubmed:
19
2
2019
medline:
2
6
2020
entrez:
19
2
2019
Statut:
ppublish
Résumé
Executive dysfunction and white matter inflammation continue to be relatively understudied in rodent models of Alzheimer's disease (AD). Behavioural inflexibility is an important component of executive dysfunction that can be further categorized as perseverative or regressive, which respectively specify whether maladaptive persistence occurs early or late during a behavioural change. Previous studies of the TgAPP21 rat model of AD (expressing pathogenic hAPP) suggested a potentially spontaneous increase of regressive behavioral inflexibility. In this study, 7-8-month-old male TgAPP21 rats were tested for behavioral flexibility, learning, and memory using an operant conditioning chamber and the Morris Water Maze (MWM). TgAPP21 rats demonstrated a regressive behavioral inflexibility during set shifting in an operant conditioning chamber (regressive errors η
Identifiants
pubmed: 30776475
pii: S0889-1591(18)30617-2
doi: 10.1016/j.bbi.2019.02.013
pii:
doi:
Substances chimiques
Amyloid beta-Protein Precursor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
25-34Subventions
Organisme : CIHR
ID : 126127
Pays : Canada
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.