Psychiatric hospitalization following antipsychotic medication cessation in first episode psychosis.
Adult
Antipsychotic Agents
/ therapeutic use
Female
Hospitalization
/ statistics & numerical data
Hospitals, Psychiatric
/ statistics & numerical data
Humans
Male
Psychotic Disorders
/ diagnosis
Recurrence
Registries
/ statistics & numerical data
Sweden
/ epidemiology
Time Factors
Withholding Treatment
/ statistics & numerical data
Young Adult
Relapse
antipsychotic medication
first episode psychosis
hospitalization
Journal
Journal of psychopharmacology (Oxford, England)
ISSN: 1461-7285
Titre abrégé: J Psychopharmacol
Pays: United States
ID NLM: 8907828
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
pubmed:
20
2
2019
medline:
2
6
2020
entrez:
20
2
2019
Statut:
ppublish
Résumé
There are questions about the risk-benefit balance of longer-term antipsychotic medication treatment following first episode psychosis, especially in relation to relapse because of dopamine supersensitivity following treatment cessation. The purpose of this study was to determine whether hospitalization rates in first episode psychosis patients are associated with length of initial oral antipsychotic medication exposure. We examined psychiatric hospitalization rates in patients experiencing first episode of psychosis from the total population of Sweden between 1 January 2007-31 December 2016 ( n=7043). We categorised patients by the length of first antipsychotic treatment (<6 months, 6 months to <1 year, 1 year to <2 years, 2 years to <5 years and ⩾5 years). Compared to those treated for <6 months, individuals receiving oral antipsychotic medications for ⩾5 years had less than half the cumulative incidence of hospitalization at all times between 1-4 years after treatment cessation. We found no evidence that hospitalization rates increased with increasing baseline antipsychotic exposure.
Sections du résumé
BACKGROUND
There are questions about the risk-benefit balance of longer-term antipsychotic medication treatment following first episode psychosis, especially in relation to relapse because of dopamine supersensitivity following treatment cessation.
AIM
The purpose of this study was to determine whether hospitalization rates in first episode psychosis patients are associated with length of initial oral antipsychotic medication exposure.
METHODS
We examined psychiatric hospitalization rates in patients experiencing first episode of psychosis from the total population of Sweden between 1 January 2007-31 December 2016 ( n=7043). We categorised patients by the length of first antipsychotic treatment (<6 months, 6 months to <1 year, 1 year to <2 years, 2 years to <5 years and ⩾5 years).
RESULTS
Compared to those treated for <6 months, individuals receiving oral antipsychotic medications for ⩾5 years had less than half the cumulative incidence of hospitalization at all times between 1-4 years after treatment cessation.
CONCLUSION
We found no evidence that hospitalization rates increased with increasing baseline antipsychotic exposure.
Identifiants
pubmed: 30777499
doi: 10.1177/0269881119827883
pmc: PMC7613091
mid: EMS150074
doi:
Substances chimiques
Antipsychotic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
532-534Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 211085
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 211085/Z/18/Z
Pays : United Kingdom
Références
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pubmed: 26527055
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pubmed: 29856564
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pubmed: 29856543
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pubmed: 29621900
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pubmed: 27802977