CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis.
Animals
Aspergillus fumigatus
/ immunology
Bronchoalveolar Lavage
CD11b Antigen
/ metabolism
Cytokines
/ metabolism
Disease Models, Animal
Female
Inflammation
/ metabolism
Invasive Pulmonary Aspergillosis
/ immunology
Kaplan-Meier Estimate
Lung
/ metabolism
Macrophage-1 Antigen
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Neutrophil Infiltration
/ immunology
Neutrophils
/ metabolism
Phagocytosis
Aspergillus fumigatus
CC-chemokine ligand 5
CD11b
complement receptor 3
phagocytosis
pneumonia
polymorphonuclear neutrophils
β2 integrins
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
20
08
2018
accepted:
15
01
2019
entrez:
20
2
2019
pubmed:
20
2
2019
medline:
1
1
2020
Statut:
epublish
Résumé
ß2 integrin receptors consist of an alpha subunit (CD11a-CD11d) and CD18 as the common beta subunit, and are differentially expressed by leukocytes. ß2 integrins are required for cell-cell interaction, transendothelial migration, uptake of opsonized pathogens, and cell signaling processes. Functional loss of CD18-termed leukocyte-adhesion deficiency type 1 (LAD1)-results in an immunocompromised state characterized by frequent occurrence of severe infections. In immunosuppressed individuals
Identifiants
pubmed: 30778357
doi: 10.3389/fimmu.2019.00123
pmc: PMC6369709
doi:
Substances chimiques
CD11b Antigen
0
Cytokines
0
Itgam protein, mouse
0
Macrophage-1 Antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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