28-Day somatic gene mutation study of 1-bromopropane in female Big Blue
1-bromopropane
Carcinogenesis
In vivo
Inhalation
Mutagenesis
Threshold
Vapor degreaser
Journal
Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Titre abrégé: Regul Toxicol Pharmacol
Pays: Netherlands
ID NLM: 8214983
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
23
10
2018
revised:
24
01
2019
accepted:
26
01
2019
pubmed:
20
2
2019
medline:
18
6
2019
entrez:
20
2
2019
Statut:
ppublish
Résumé
A 2-year inhalation rat and mouse cancer study by the National Toxicology Program (NTP) on 1-bromopropane, a brominated solvent most commonly used as a vapor degreaser, showed significant increase in tumors in the lung of female mice and in the large intestine of male and female rats. The most sensitive endpoint was lung tumors in female mice. Mice of both sexes had hyperplasia and inflammation of the nose and showed regeneration of lung tissue. The NTP assumed that these tumors were due to genotoxic effects and that a linear dose-response relationship was appropriate. It is plausible that, similar to chloroform, hyperplasia and inflammation are required as initial events for tumor development. If true, then a threshold-based model may be more appropriate for 1-bromopropane. To test this hypothesis, a 28-day repeat dose inhalation Big Blue
Identifiants
pubmed: 30779931
pii: S0273-2300(19)30042-X
doi: 10.1016/j.yrtph.2019.01.034
pii:
doi:
Substances chimiques
Carcinogens
0
Hydrocarbons, Brominated
0
1-bromopropane
Y9746DNE68
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-7Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.