N⁶-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling.
3' Untranslated Regions
/ genetics
Adenosine
/ analogs & derivatives
Adenosine Deaminase
/ genetics
Carcinogenesis
/ genetics
Cell Line, Tumor
Cytidine Deaminase
/ genetics
Gene Expression Regulation, Neoplastic
Glioma
/ genetics
Histones
/ genetics
Humans
Methyltransferases
/ genetics
Neoplastic Stem Cells
/ metabolism
Nucleic Acid Conformation
Proteins
/ genetics
RNA Editing
/ genetics
RNA Splicing
/ genetics
RNA-Binding Proteins
/ genetics
Signal Transduction
/ genetics
Transcription, Genetic
GSCs
METTL3
RNA editing
glioblastoma
histone activation
m6A
m6A reader
splicing
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
13 02 2019
13 02 2019
Historique:
received:
28
09
2018
revised:
22
11
2018
accepted:
28
11
2018
entrez:
21
2
2019
pubmed:
20
2
2019
medline:
20
2
2019
Statut:
epublish
Résumé
Despite recent advances in
Identifiants
pubmed: 30781903
pii: genes10020141
doi: 10.3390/genes10020141
pmc: PMC6410051
pii:
doi:
Substances chimiques
3' Untranslated Regions
0
Histones
0
Proteins
0
RNA-Binding Proteins
0
N-methyladenosine
CLE6G00625
Methyltransferases
EC 2.1.1.-
METTL3 protein, human
EC 2.1.1.62
ADAR protein, human
EC 3.5.4.37
Adenosine Deaminase
EC 3.5.4.4
APOBEC3A protein, human
EC 3.5.4.5
Cytidine Deaminase
EC 3.5.4.5
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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