Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
11 04 2019
11 04 2019
Historique:
received:
18
09
2018
accepted:
10
02
2019
pubmed:
21
2
2019
medline:
18
12
2019
entrez:
21
2
2019
Statut:
ppublish
Résumé
Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities, often associated with an aggressive clinical course. Angioimmunoblastic T-cell lymphoma (AITL) and PTCL-not otherwise specified (PTCL-NOS) are the 2 most frequent categories, accounting for >50% of PTCLs. Gene expression profiling (GEP) defined molecular signatures for AITL and delineated biological and prognostic subgroups within PTCL-NOS (PTCL-GATA3 and PTCL-TBX21). Genomic copy number (CN) analysis and targeted sequencing of these molecular subgroups revealed unique CN abnormalities (CNAs) and oncogenic pathways, indicating distinct oncogenic evolution. PTCL-GATA3 exhibited greater genomic complexity that was characterized by frequent loss or mutation of tumor suppressor genes targeting the
Identifiants
pubmed: 30782609
pii: S0006-4971(20)42637-0
doi: 10.1182/blood-2018-09-872549
pmc: PMC6460420
doi:
Substances chimiques
GATA3 Transcription Factor
0
GATA3 protein, human
0
T-Box Domain Proteins
0
T-box transcription factor TBX21
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1664-1676Subventions
Organisme : NCI NIH HHS
ID : P01 CA229100
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103427
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103471
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR027754
Pays : United States
Organisme : NCRR NIH HHS
ID : P20 RR016469
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA157581
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA036727
Pays : United States
Organisme : NCRR NIH HHS
ID : P20 RR018788
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA136411
Pays : United States
Organisme : NCI NIH HHS
ID : UH2 CA206127
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA107399
Pays : United States
Informations de copyright
© 2019 by The American Society of Hematology.
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