Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study.
Child Development
Child, Preschool
Female
HIV Infections
/ complications
Humans
Infant
Infant, Newborn
Kaplan-Meier Estimate
Linear Models
Longitudinal Studies
Male
Patient Discharge
/ statistics & numerical data
Prevalence
ROC Curve
Recurrence
Risk Factors
Severe Acute Malnutrition
/ mortality
Zambia
/ epidemiology
Zimbabwe
/ epidemiology
Africa
HIV
enteropathy
malnutrition
microbiota
mortality
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
entrez:
21
2
2019
pubmed:
21
2
2019
medline:
14
2
2020
Statut:
epublish
Résumé
Mortality among children hospitalised for complicated severe acute malnutrition (SAM) remains high despite the implementation of WHO guidelines, particularly in settings of high HIV prevalence. Children continue to be at high risk of morbidity, mortality and relapse after discharge from hospital although long-term outcomes are not well documented. Better understanding the pathogenesis of SAM and the factors associated with poor outcomes may inform new therapeutic interventions. The Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM) study is a longitudinal observational cohort that aims to evaluate the short-term and long-term clinical outcomes of HIV-positive and HIV-negative children with complicated SAM, and to identify the risk factors at admission and discharge from hospital that independently predict poor outcomes. Children aged 0-59 months hospitalised for SAM are being enrolled at three tertiary hospitals in Harare, Zimbabwe and Lusaka, Zambia. Longitudinal mortality, morbidity and nutritional data are being collected at admission, discharge and for 48 weeks post discharge. Nested laboratory substudies are exploring the role of enteropathy, gut microbiota, metabolomics and cellular immune function in the pathogenesis of SAM using stool, urine and blood collected from participants and from well-nourished controls. The study is approved by the local and international institutional review boards in the participating countries (the Joint Research Ethics Committee of the University of Zimbabwe, Medical Research Council of Zimbabwe and University of Zambia Biomedical Research Ethics Committee) and the study sponsor (Queen Mary University of London). Caregivers provide written informed consent for each participant. Findings will be disseminated through peer-reviewed journals, conference presentations and to caregivers at face-to-face meetings.
Identifiants
pubmed: 30782694
pii: bmjopen-2018-023077
doi: 10.1136/bmjopen-2018-023077
pmc: PMC6361330
doi:
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e023077Subventions
Organisme : Wellcome Trust
ID : 107634/Z/15/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12023/17
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 108065/Z/15/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12023/26
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206225/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K012711/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U122886353
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206455/Z/17/Z
Pays : United Kingdom
Investigateurs
Virginia Sauramba
(V)
Adlight Dandadzi
(A)
Chipo Kureva
(C)
Johnson Mushonga
(J)
Eddington Mpofu
(E)
Washington Dune
(W)
Tafadzwa Chidhanguro
(T)
Sibongile Nkiwane
(S)
Sandra Rukobo
(S)
Margaret Govha
(M)
Patience Mashayanembwa
(P)
Leah Chidamba
(L)
Bernard Chasekwa
(B)
Joice Tome
(J)
Rachel Makasi
(R)
Wellington Murenjekekwa
(W)
Theodore Chidawanyika
(T)
Blessing Tsenesa
(B)
Stephen Moyo
(S)
Penias Nyamwino
(P)
Pururudzai Simango
(P)
Shepherd Seremwe
(S)
Lovemore Chingaoma And Sarudzai Kasaru
(LC)
Andreck Tembo
(A)
Mary Mpundu
(M)
Evelyn Nyendwa
(E)
Gwendolyn Nayame
(G)
Dalitso Tembo
(D)
Sophreen Mwaba
(S)
Esther Chilala
(E)
Lucy Macwani
(L)
Tenzeni Dumba
(T)
Miyoba Chipunza
(M)
Lydia Kazhila
(L)
Temwaninge Gondwe
(T)
Dennis Phiri
(D)
Mpala Mwanza
(M)
Kanekwa Zyambo
(K)
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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