Frailty in patients undergoing transcatheter aortic valve implantation: a protocol for a systematic review.

Aged Aortic Valve Stenosis / epidemiology Frail Elderly Frailty / epidemiology Humans Quality of Life Transcatheter Aortic Valve Replacement Treatment Outcome Systematic Reviews as Topic
aortic stenosis frailty prognosis protocol systematic review transcathter aortic valve implantation

Journal

BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874

Informations de publication

Date de publication:
19 Feb 2019
Historique:
entrez: 21 2 2019
pubmed: 21 2 2019
medline: 25 2 2020
Statut: epublish

Résumé

Aortic stenosis is a significant cause of morbidity and mortality in older patients. The advent of transcatheter aortic valve implantation (TAVI) offers an alternative to surgical aortic valve replacement for patients with severe symptomatic aortic stenosis who are at high or intermediate risk of adverse events. Existing evidence highlights the importance of frailty as a predictor of poor outcomes post-TAVI. The objective of this study is to review the operationalisation of frailty instruments for TAVI recipients and determine clinical outcomes and the change in quality of life in frail patients undergoing TAVI. Methods are reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 checklist. We will search relevant databases to identify published, completed but unpublished and ongoing studies. We will include studies of patients with aortic stenosis, diagnosed as frail and who underwent a TAVI procedure that report mortality, clinical outcomes or health-related quality of life. Retrospective or prospective cohort studies, randomised controlled trials and non-randomised controlled trials will be eligible for inclusion. Two researchers will independently screen articles for inclusion, with disagreements resolved by a third reviewer. One researcher will extract data with audit by a second researcher. The risk of bias in studies will be evaluated using the Quality in Prognosis Studies tool. Meta-analysis of mortality, survival curve and the change in quality of life will be performed if appropriate. Subgroup analysis, sensitivity analysis and meta-regression will be performed if necessary. Due to the nature of this study, no ethical issues are foreseen. We will disseminate the results of our systematic review through a peer-reviewed journal. CRD42018090597.

Identifiants

DOI: 10.1136/bmjopen-2018-024163 PMID: 30782896 PMC: PMC6377546
pubmed: 30782896
pii: bmjopen-2018-024163
doi: 10.1136/bmjopen-2018-024163
pmc: PMC6377546
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e024163

Informations de copyright

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

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Auteurs

Zhe Li (Z)

Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Centre for Medical Evidence, Decision Integrity & Clinical Impact (MEDICI), Western University, London, Ontario, Canada.
Department of Anesthesia & Perioperative Medicine, Western University, London, Ontario, Canada.
Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Emily Dawson (E)

Centre for Medical Evidence, Decision Integrity & Clinical Impact (MEDICI), Western University, London, Ontario, Canada.
Department of Anesthesia & Perioperative Medicine, Western University, London, Ontario, Canada.

Jessica Moodie (J)

Centre for Medical Evidence, Decision Integrity & Clinical Impact (MEDICI), Western University, London, Ontario, Canada.
Department of Anesthesia & Perioperative Medicine, Western University, London, Ontario, Canada.

Janet Martin (J)

Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Centre for Medical Evidence, Decision Integrity & Clinical Impact (MEDICI), Western University, London, Ontario, Canada.
Department of Anesthesia & Perioperative Medicine, Western University, London, Ontario, Canada.
Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Rodrigo Bagur (R)

Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada.
ORCID: 0000-0003-1888-9429

Davy Cheng (D)

Centre for Medical Evidence, Decision Integrity & Clinical Impact (MEDICI), Western University, London, Ontario, Canada.
Department of Anesthesia & Perioperative Medicine, Western University, London, Ontario, Canada.
Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Division of Critical Care Medicine, Department of Medicine, Western University, London, Ontario, Canada.

Bob Kiaii (B)

Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Division of Cardiac Surgery, Department of Surgery, Western University, London, Ontario, Canada.

Ava John-Baptiste (A)

Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Centre for Medical Evidence, Decision Integrity & Clinical Impact (MEDICI), Western University, London, Ontario, Canada.
Department of Anesthesia & Perioperative Medicine, Western University, London, Ontario, Canada.
Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Interfaculty Program in Public Health, Western University, London, Ontario, Canada.
ORCID: 0000-0001-6108-1105

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Frailty in patients undergoing transcatheter...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Obstacle à l'éjection ventriculaire › Sténose aortique › Frailty in patients undergoing transcatheter...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Personne âgée fragile › Frailty in patients undergoing transcatheter...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fragilité › Frailty in patients undergoing transcatheter...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Frailty in patients undergoing transcatheter...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Frailty in patients undergoing transcatheter...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie thoracique › Procédures de chirurgie cardiaque › Implantation de valve prothétique cardiaque › Remplacement valvulaire aortique par cathéter › Frailty in patients undergoing transcatheter...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Frailty in patients undergoing transcatheter...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Moyens de communication › Publications › Littérature de revue comme sujet › Revues systématiques comme sujet › Frailty in patients undergoing transcatheter...