Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.
Black or African American
/ genetics
Asthma
/ epidemiology
Chromosomes, Human, Pair 12
/ genetics
Chromosomes, Human, Pair 17
/ genetics
Chromosomes, Human, Pair 8
/ genetics
Genetic Loci
Genetic Predisposition to Disease
/ genetics
Genome-Wide Association Study
Hispanic or Latino
/ genetics
Humans
Polymorphism, Single Nucleotide
/ genetics
United States
/ epidemiology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 02 2019
20 02 2019
Historique:
received:
21
06
2018
accepted:
08
01
2019
entrez:
22
2
2019
pubmed:
23
2
2019
medline:
4
4
2019
Statut:
epublish
Résumé
Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12-q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.
Identifiants
pubmed: 30787307
doi: 10.1038/s41467-019-08469-7
pii: 10.1038/s41467-019-08469-7
pmc: PMC6382865
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
880Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM116065
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113003
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141845
Pays : United States
Organisme : NIH HHS
ID : S10 OD018522
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI106683
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI145818
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL112088
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI079139
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL104608
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132476
Pays : United States
Organisme : NHLBI NIH HHS
ID : R37 HL068546
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121334
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129239
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115428
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118267
Pays : United States
Investigateurs
Ayola Akim Adegnika
(AA)
Ganiyu Arinola
(G)
Ulysse Ateba-Ngoa
(U)
Gerardo Ayestas
(G)
Hrafnhildur Bjarnadóttir
(H)
Adolfo Correa
(A)
Said Omar Leiva Erazo
(SOL)
Marilyn G Foreman
(MG)
Cassandra Foster
(C)
Li Gao
(L)
Jingjing Gao
(J)
Leslie Grammer
(L)
Mark Hansen
(M)
Tina Hartert
(T)
Yijuan Hu
(Y)
Iain Königsberg
(I)
Kwang-Youn A Kim
(KA)
Pamela Landaverde-Torres
(P)
Javier Marrugo
(J)
Beatriz Martinez
(B)
Rosella Martinez
(R)
Luis F Mayorga
(LF)
Delmy-Aracely Mejia-Mejia
(DA)
Catherine Meza
(C)
Solomon Musani
(S)
Shaila Musharoff
(S)
Oluwafemi Oluwole
(O)
Maria Pino-Yanes
(M)
Hector Ramos
(H)
Allan Saenz
(A)
Maureen Samms-Vaughan
(M)
Robert Schleimer
(R)
Alan F Scott
(AF)
Suyash S Shringarpure
(SS)
Wei Song
(W)
Zachary A Szpiech
(ZA)
Raul Torres
(R)
Gloria Varela
(G)
Olga Marina Vasquez
(OM)
Francisco M De La Vega
(FM)
Lorraine B Ware
(LB)
Maria Yazdanbakhsh
(M)
Commentaires et corrections
Type : ErratumIn
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