Brain activation during disorder-related script-driven imagery in panic disorder: a pilot study.
Adult
Amygdala
/ diagnostic imaging
Anxiety Disorders
/ diagnostic imaging
Brain
/ diagnostic imaging
Brain Mapping
Emotions
/ physiology
Fear
/ physiology
Female
Gyrus Cinguli
/ diagnostic imaging
Humans
Imagery, Psychotherapy
/ methods
Imagination
/ physiology
Magnetic Resonance Imaging
Male
Panic Disorder
/ diagnostic imaging
Pilot Projects
Prefrontal Cortex
/ diagnostic imaging
Surveys and Questionnaires
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 02 2019
20 02 2019
Historique:
received:
24
01
2018
accepted:
14
01
2019
entrez:
22
2
2019
pubmed:
23
2
2019
medline:
9
9
2020
Statut:
epublish
Résumé
Despite considerable effort, the neural correlates of altered threat-related processing in panic disorder (PD) remain inconclusive. Mental imagery of disorder-specific situations proved to be a powerful tool to investigate dysfunctional threat processing in anxiety disorders. The current functional magnetic resonance imaging (fMRI) study aimed at investigating brain activation in PD patients during disorder-related script-driven imagery. Seventeen PD patients and seventeen healthy controls (HC) were exposed to newly developed disorder-related and neutral narrative scripts while brain activation was measured with fMRI. Participants were encouraged to imagine the narrative scripts as vividly as possible and they rated their script-induced emotional states after the scanning session. PD patients rated disorder-related scripts as more arousing, unpleasant and anxiety-inducing as compared to HC. Patients relative to HC showed elevated activity in the right amygdala and the brainstem as well as decreased activity in the rostral anterior cingulate cortex, and the medial and lateral prefrontal cortex to disorder-related vs. neutral scripts. The results suggest altered amygdala/ brainstem and prefrontal cortex engagement and point towards the recruitment of brain networks with opposed activation patterns in PD patients during script-driven imagery.
Identifiants
pubmed: 30787382
doi: 10.1038/s41598-019-38990-0
pii: 10.1038/s41598-019-38990-0
pmc: PMC6382839
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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