Regulation of leukocyte function by citric acid cycle intermediates.
citrate
fumarate
itaconate
metabolic reprogramming
succinate
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
01
11
2018
revised:
01
02
2019
accepted:
11
02
2019
pubmed:
23
2
2019
medline:
12
5
2020
entrez:
22
2
2019
Statut:
ppublish
Résumé
Cellular metabolism is a means of generating ATP to provide energy for key cellular functions. However, recent research shows that citric acid cycle intermediates target vital cellular functions of the innate immune system. Succinate, itaconate, citrate, and fumarate have been shown to mediate or regulate important myeloid cell functions during infection and inflammation. This review covers the regulatory functions of citric acid cycle intermediates in myeloid cells and discusses potential translational applications, key mechanistic questions, and future research directions.
Identifiants
pubmed: 30791134
doi: 10.1002/JLB.3MIR1118-415R
pmc: PMC6597293
mid: NIHMS1012222
doi:
Substances chimiques
Fumarates
0
Reactive Oxygen Species
0
Succinates
0
Citric Acid
2968PHW8QP
Succinic Acid
AB6MNQ6J6L
itaconic acid
Q4516562YH
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105-117Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM121711
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM108554
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM104306
Pays : United States
Organisme : NIGMS NIH HHS
ID : K08 GM123345
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM119197
Pays : United States
Informations de copyright
©2019 Society for Leukocyte Biology.
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