Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.
Animals
Arachidonate 12-Lipoxygenase
/ biosynthesis
Arachidonate 15-Lipoxygenase
/ biosynthesis
Gene Deletion
Gene Expression Regulation, Enzymologic
Insulin-Secreting Cells
/ enzymology
Isoxazoles
/ pharmacology
Mice
Mice, Knockout
Naphthalenes
/ pharmacology
Oxidative Stress
Streptozocin
/ toxicity
diabetes
lipoxygenase pathway
oxidative stress
pancreatic islet
reactive oxygen species (ROS)
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
19 04 2019
19 04 2019
Historique:
received:
10
12
2018
revised:
12
02
2019
pubmed:
23
2
2019
medline:
17
10
2019
entrez:
23
2
2019
Statut:
ppublish
Résumé
In type 1 diabetes, an autoimmune event increases oxidative stress in islet β cells, giving rise to cellular dysfunction and apoptosis. Lipoxygenases are enzymes that catalyze the oxygenation of polyunsaturated fatty acids that can form lipid metabolites involved in several biological functions, including oxidative stress. 12-Lipoxygenase and 12/15-lipoxygenase are related but distinct enzymes that are expressed in pancreatic islets, but their relative contributions to oxidative stress in these regions are still being elucidated. In this study, we used mice with global genetic deletion of the genes encoding 12-lipoxygenase (
Identifiants
pubmed: 30792307
pii: S0021-9258(20)36314-6
doi: 10.1074/jbc.RA118.007102
pmc: PMC6484126
doi:
Substances chimiques
12-15-lipoxygenase
0
Isoxazoles
0
ML351 compound
0
Naphthalenes
0
Streptozocin
5W494URQ81
Arachidonate 12-Lipoxygenase
EC 1.13.11.31
Arachidonate 15-Lipoxygenase
EC 1.13.11.33
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
6612-6620Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK060581
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK097512
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM077229
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK105588
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK102492
Pays : United States
Organisme : NIDDK NIH HHS
ID : R03 DK115990
Pays : United States
Informations de copyright
© 2019 Conteh et al.
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