Mitochondrial localization, import, and mitochondrial function of the androgen receptor.
androgen receptor
castration-resistant
cell signaling
gene transcription
genomic signaling
mitochondria
mitochondrial localization sequence
nongenomic signaling
nuclear receptor
oxidative phosphorylation
prostate cancer
retrograde signaling
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
19 04 2019
19 04 2019
Historique:
received:
15
11
2018
revised:
14
12
2018
pubmed:
23
2
2019
medline:
17
10
2019
entrez:
23
2
2019
Statut:
ppublish
Résumé
Nuclear localization of androgen receptor (AR) directs transcriptional regulation of a host of genes, referred to as genomic signaling. Additionally, nonnuclear or nongenomic activities of the AR have long been described, but understanding of these activities remains elusive. Here, we report that AR is imported into and localizes to mitochondria and has a novel role in regulating multiple mitochondrial processes. Employing complementary experimental approaches of AR knockdown in AR-expressing cells and ectopic AR expression in AR-deficient cells, we demonstrate an inverse relationship between AR expression and mitochondrial DNA (mtDNA) content and transcription factor A, mitochondrial (TFAM), a regulator of mtDNA content. We show that AR localizes to mitochondria in prostate tissues and cell lines and is imported into mitochondria
Identifiants
pubmed: 30792308
pii: S0021-9258(20)36315-8
doi: 10.1074/jbc.RA118.006727
pmc: PMC6484137
doi:
Substances chimiques
DNA-Binding Proteins
0
Mitochondrial Proteins
0
Protein Sorting Signals
0
Receptors, Androgen
0
TFAM protein, human
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6621-6634Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK079626
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204430
Pays : United States
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