Circadian clock protein Rev-erbα regulates neuroinflammation.
Animals
Astrocytes
/ metabolism
Cell Death
Circadian Clocks
Gene Deletion
Gliosis
/ pathology
Hippocampus
/ pathology
Inflammation
/ metabolism
Lipopolysaccharides
Mice, Inbred C57BL
Mice, Knockout
Microglia
/ metabolism
NF-kappa B
/ metabolism
Nerve Net
/ metabolism
Neurons
/ metabolism
Nuclear Receptor Subfamily 1, Group D, Member 1
/ deficiency
Signal Transduction
Rev-erbα
circadian
microglia
neuroinflammation
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
12 03 2019
12 03 2019
Historique:
pubmed:
23
2
2019
medline:
7
5
2019
entrez:
23
2
2019
Statut:
ppublish
Résumé
Circadian dysfunction is a common attribute of many neurodegenerative diseases, most of which are associated with neuroinflammation. Circadian rhythm dysfunction has been associated with inflammation in the periphery, but the role of the core clock in neuroinflammation remains poorly understood. Here we demonstrate that Rev-erbα, a nuclear receptor and circadian clock component, is a mediator of microglial activation and neuroinflammation. We observed time-of-day oscillation in microglial immunoreactivity in the hippocampus, which was disrupted in Rev-erbα
Identifiants
pubmed: 30792350
pii: 1812405116
doi: 10.1073/pnas.1812405116
pmc: PMC6421453
doi:
Substances chimiques
Lipopolysaccharides
0
NF-kappa B
0
Nuclear Receptor Subfamily 1, Group D, Member 1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5102-5107Subventions
Organisme : NIA NIH HHS
ID : R01 AG054517
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH093429
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG060769
Pays : United States
Organisme : NINDS NIH HHS
ID : K25 NS083754
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102870
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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