Cachexia and advanced dementia.

Aging Anorexia / complications Cachexia / complications Dementia / complications Disease Susceptibility Frailty Humans Sarcopenia / epidemiology Translational Research, Biomedical
Advanced dementia Cachexia Failure to thrive Frailty Sarcopenia Supportive care

Journal

Journal of cachexia, sarcopenia and muscle
ISSN: 2190-6009
Titre abrégé: J Cachexia Sarcopenia Muscle
Pays: Germany
ID NLM: 101552883

Informations de publication

Date de publication:
04 2019
Historique:
received: 24 08 2018
accepted: 20 11 2018
pubmed: 23 2 2019
medline: 4 6 2020
entrez: 23 2 2019
Statut: ppublish

Résumé

Cachexia is a complex metabolic process that is associated with several end-stage organ diseases. It is known to be also associated with advanced dementia, although the pathophysiologic mechanisms are still largely unknown. The present narrative review is aimed at presenting recent insights concerning the pathophysiology of weight loss and wasting syndrome in dementia, the putative mechanisms involved in the dysregulation of energy balance, and the interplay among the chronic clinical conditions of sarcopenia, malnutrition, and frailty in the elderly. We discuss the clinical implications of these new insights, with particular attention to the challenging question of nutritional needs in advanced dementia and the utility of tube feeding in order to optimize the management of end-stage dementia.

Identifiants

DOI: 10.1002/jcsm.12380 PMID: 30794350 PMC: PMC6463474
pubmed: 30794350
doi: 10.1002/jcsm.12380
pmc: PMC6463474
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

263-277

Informations de copyright

© 2019 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders.

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Auteurs

Cecilia Minaglia (C)

Department of Internal Medicine and Medical Specialties (DIMI), Section of Geriatrics, University of Genoa, Genoa, Italy.

Chiara Giannotti (C)

Department of Internal Medicine and Medical Specialties (DIMI), Section of Geriatrics, University of Genoa, Genoa, Italy.

Virginia Boccardi (V)

Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.

Patrizia Mecocci (P)

Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.

Gianluca Serafini (G)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Section of Psychiatry, I.R.C.C.S. Ospedale Policlinico San Martino, Genoa, Italy.

Patrizio Odetti (P)

Department of Internal Medicine and Medical Specialties (DIMI), Section of Geriatrics, University of Genoa, Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Fiammetta Monacelli (F)

Department of Internal Medicine and Medical Specialties (DIMI), Section of Geriatrics, University of Genoa, Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Cachexia and advanced dementia.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes digestifs › Anorexie › Cachexia and advanced dementia.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Cachexie › Cachexia and advanced dementia.
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Cachexia and advanced dementia.
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Cachexia and advanced dementia.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fragilité › Cachexia and advanced dementia.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cachexia and advanced dementia.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Amyotrophie › Sarcopénie › Cachexia and advanced dementia.
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Recherche biomédicale › Recherche médicale translationnelle › Cachexia and advanced dementia.