Genomic Imprinting and Physiological Processes in Mammals.
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
21 02 2019
21 02 2019
Historique:
received:
26
06
2018
revised:
08
01
2019
accepted:
24
01
2019
entrez:
23
2
2019
pubmed:
23
2
2019
medline:
7
1
2020
Statut:
ppublish
Résumé
Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents. However, epigenetic studies have demonstrated violations to this rule that are necessary for mammalian physiology; the most notable parental allele expression phenomenon is genomic imprinting. With the identification of endogenous imprinted genes, genomic imprinting became well-established as an epigenetic mechanism in which the expression pattern of a parental allele influences phenotypic expression. The expanding study of genomic imprinting is revealing a significant impact on brain functions and associated diseases. Here, we review key milestones in the field of imprinting and discuss mechanisms and systems in which imprinted genes exert a significant role.
Identifiants
pubmed: 30794780
pii: S0092-8674(19)30106-0
doi: 10.1016/j.cell.2019.01.043
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
952-965Subventions
Organisme : Wellcome Trust
ID : 210757/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 210757/Z/18
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K011332/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P002307/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S000437/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/B/000C0426
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R009791/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P008623/1
Pays : United Kingdom
Investigateurs
Valter Tucci
(V)
Marisa S Bartolomei
(MS)
Nissim Benvenisty
(N)
Déborah Bourc'his
(D)
Marika Charalambous
(M)
Catherine Dulac
(C)
Robert Feil
(R)
Juliane Glaser
(J)
Lisa Huelsmann
(L)
Rosalind M John
(RM)
Gráinne I McNamara
(GI)
Kim Moorwood
(K)
Francoise Muscatelli
(F)
Hiroyuki Sasaki
(H)
Beverly I Strassmann
(BI)
Claudius Vincenz
(C)
Jon Wilkins
(J)
Anthony R Isles
(AR)
Gavin Kelsey
(G)
Anne C Ferguson-Smith
(AC)
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.