Overview of the cholinergic contribution to gait, balance and falls in Parkinson's disease.
Acetylcholine
Balance
Falls
Gait
Parkinson's disease
Journal
Parkinsonism & related disorders
ISSN: 1873-5126
Titre abrégé: Parkinsonism Relat Disord
Pays: England
ID NLM: 9513583
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
19
11
2018
revised:
02
01
2019
accepted:
13
02
2019
pubmed:
24
2
2019
medline:
10
5
2020
entrez:
24
2
2019
Statut:
ppublish
Résumé
Mobility deficits, including gait disturbance, balance impairments and falls, are common features of Parkinson's disease (PD) that negatively impact quality of life. Mobility deficits respond poorly to dopaminergic medications, indicating a role for additional neurotransmitters. Due to the critical role of cortical input to gait and balance, acetylcholine-an essential neurotransmitter system for attention-has become an area of interest for mobility. This review aimed to identify the role of cholinergic function on gait, balance, and falls in PD using three techniques; pharmacological, imaging, and electrophysiological. Studies supported the role of the cholinergic system for mobility in PD, with the most promising evidence indicating a role in falls. Imaging studies demonstrated involvement of anterior cholinergic (basal forebrain) systems in gait, and posterior (brainstem) systems in balance. However, this review identified a small number of studies which used varying protocols, making comparisons difficult. Further studies are warranted, measuring comprehensive gait and balance characteristics as well as gold standard falls detection to further quantify the relationship between ACh and mobility in PD.
Identifiants
pubmed: 30796007
pii: S1353-8020(19)30063-X
doi: 10.1016/j.parkreldis.2019.02.017
pmc: PMC6682416
mid: NIHMS1024202
pii:
doi:
Substances chimiques
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
20-30Subventions
Organisme : NINDS NIH HHS
ID : P50 NS062684
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG006457
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.
Références
Parkinsons Dis. 2012;2012:918719
pubmed: 22135764
Lancet Neurol. 2006 Nov;5(11):974-83
pubmed: 17052664
Mov Disord. 2016 Dec;31(12):1829-1836
pubmed: 27621153
J Neurol Neurosurg Psychiatry. 2004 Apr;75(4):555-9
pubmed: 15026495
J Alzheimers Dis. 2017;60(4):1295-1312
pubmed: 29036826
Phys Ther. 2015 Mar;95(3):461-70
pubmed: 25504484
Neurosci Biobehav Rev. 2016 May;64:326-45
pubmed: 26915926
J Gerontol A Biol Sci Med Sci. 2013 Jul;68(7):820-7
pubmed: 23250001
Parkinsonism Relat Disord. 2015 Mar;21(3):236-42
pubmed: 25572498
Can J Neurol Sci. 2016 Sep;43(5):626-34
pubmed: 27670207
Neurology. 2009 Jul 28;73(4):256-7
pubmed: 19535769
Neurosci Lett. 2012 Apr 18;514(2):169-72
pubmed: 22414859
Mov Disord. 2008 Feb 15;23(3):329-42; quiz 472
pubmed: 18058946
J Gerontol A Biol Sci Med Sci. 2017 Nov 9;72(12):1656-1662
pubmed: 28472409
J Neurol. 2017 Nov;264(11):2268-2276
pubmed: 28948348
Phys Ther. 2016 Sep;96(9):1364-71
pubmed: 27034314
Mov Disord. 2015 Sep;30(10):1361-70
pubmed: 26095928
J Cereb Blood Flow Metab. 2012 Aug;32(8):1609-17
pubmed: 22569194
Front Aging Neurosci. 2016 May 09;8:104
pubmed: 27242515
J Comp Neurol. 1983 Feb 20;214(2):170-97
pubmed: 6841683
J Neural Transm (Vienna). 2008 May;115(5):737-43
pubmed: 18188496
Physiotherapy. 2017 Dec;103(4):459-464
pubmed: 27913063
Disabil Rehabil. 2018 Sep;40(19):2236-2241
pubmed: 28573883
Front Synaptic Neurosci. 2014 Oct 21;6:22
pubmed: 25374536
J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):929-35
pubmed: 17237140
J Clin Invest. 2010 Aug;120(8):2745-54
pubmed: 20628197
Neurology. 2007 Feb 13;68(7):484-8
pubmed: 17296913
Mol Psychiatry. 2013 Aug;18(8):864-74
pubmed: 23164816
Mov Disord. 2010 Jul 30;25(10):1519-20
pubmed: 20629167
Brain. 2013 Nov;136(Pt 11):3282-9
pubmed: 24056537
Mov Disord. 2011 Dec;26(14):2496-503
pubmed: 21898597
J Parkinsons Dis. 2017;7(3):465-470
pubmed: 28671141
Neurology. 2009 Nov 17;73(20):1670-6
pubmed: 19917989
Behav Brain Res. 1991 Dec 20;46(2):123-33
pubmed: 1664728
J Cereb Blood Flow Metab. 1999 Oct;19(10):1150-63
pubmed: 10532640
Parkinsons Dis. 2012;2012:375419
pubmed: 22135761
Can J Public Health. 1992 Jul-Aug;83 Suppl 2:S7-11
pubmed: 1468055
Neuron. 2007 Jul 19;55(2):187-99
pubmed: 17640522
Curr Neuropharmacol. 2013 May;11(3):315-35
pubmed: 24179466
Ann Pharmacother. 1999 Apr;33(4):441-50
pubmed: 10332536
Neurology. 2008 Jun 3;70(23):2241-7
pubmed: 18519873
J Neurosci. 2013 Oct 16;33(42):16522-39
pubmed: 24133257
Eur J Neurosci. 2004 Apr;19(7):1950-62
pubmed: 15078569
Lancet. 2016 Sep 17;388(10050):1170-82
pubmed: 27524393
Parkinsonism Relat Disord. 2006 Jan;12(1):35-41
pubmed: 16271496
Int Psychogeriatr. 2002 Sep;14(3):307-10
pubmed: 12475091
World Neurosurg. 2017 Jun;102:72-78
pubmed: 28279773
IEEE J Biomed Health Inform. 2016 May;20(3):838-847
pubmed: 25850097
Neurology. 2013 Oct 29;81(18):1611-6
pubmed: 24078735
JAMA Neurol. 2018 Feb 1;75(2):169-178
pubmed: 29255885
Age Ageing. 2013 Sep;42(5):567-76
pubmed: 23868092
Mov Disord. 2017 May;32(5):693-704
pubmed: 28164375
Clin Pharmacol Ther. 2007 Feb;81(2):235-41
pubmed: 17192773
Lancet Neurol. 2016 Mar;15(3):249-58
pubmed: 26795874
Behav Brain Res. 2011 Aug 10;221(2):564-73
pubmed: 20060022
Brain. 2012 Sep;135(Pt 9):2779-88
pubmed: 22961550
Neurology. 2002 Aug 13;59(3):392-7
pubmed: 12177373
Eur Neurol. 2015;74(1-2):86-91
pubmed: 26288230
Arch Phys Med Rehabil. 2007 Dec;88(12):1593-600
pubmed: 18047873
Neurology. 2010 Oct 5;75(14):1263-9
pubmed: 20810998
Hear Res. 2013 Jan;295:58-66
pubmed: 23099209
Exp Brain Res. 2000 Dec;135(4):455-61
pubmed: 11156309