Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
23 05 2019
23 05 2019
Historique:
received:
29
10
2018
accepted:
18
02
2019
pubmed:
24
2
2019
medline:
24
12
2019
entrez:
24
2
2019
Statut:
ppublish
Résumé
Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen receptor (CAR) T cells (CARTs) to T-ALL remains challenging because the shared expression of target antigens between CARTs and T-ALL blasts leads to CART fratricide. CD1a is exclusively expressed in cortical T-ALL (coT-ALL), a major subset of T-ALL, and retained at relapse. This article reports that the expression of CD1a is mainly restricted to developing cortical thymocytes, and neither CD34
Identifiants
pubmed: 30796021
pii: S0006-4971(20)42537-6
doi: 10.1182/blood-2018-10-882944
pmc: PMC6554538
doi:
Substances chimiques
Antigens, CD1
0
CD1a antigen
0
Receptors, Chimeric Antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2291-2304Subventions
Organisme : Medical Research Council
ID : MR/R006237/1
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 by The American Society of Hematology.
Références
J Virol. 2003 Feb;77(3):2081-92
pubmed: 12525643
Immunology. 2018 Jun;154(2):196-203
pubmed: 29460282
Sci Transl Med. 2013 Mar 20;5(177):177ra38
pubmed: 23515080
Mol Ther. 2017 Mar 1;25(3):580-592
pubmed: 28187946
J Exp Med. 2017 Nov 6;214(11):3361-3379
pubmed: 28947612
Blood. 2015 Aug 20;126(8):983-92
pubmed: 26056165
Cancer Cell. 2011 Apr 12;19(4):484-97
pubmed: 21481790
Nat Immunol. 2016 Oct;17(10):1159-66
pubmed: 27548435
AIDS. 2014 Jun 1;28(9):1261-72
pubmed: 24732774
Stem Cell Reports. 2016 Oct 11;7(4):602-618
pubmed: 27666791
Science. 2004 Oct 8;306(5694):269-71
pubmed: 15472075
Nat Med. 2017 Dec;23(12):1416-1423
pubmed: 29131157
Exp Hematol. 2017 Jul;51:7-16
pubmed: 28412288
Leukemia. 1995 Oct;9(10):1783-6
pubmed: 7564526
Blood. 2017 Jun 22;129(25):3322-3331
pubmed: 28408462
Blood. 2015 Aug 13;126(7):833-41
pubmed: 25966987
N Engl J Med. 2014 Oct 16;371(16):1507-17
pubmed: 25317870
J Exp Med. 2009 Dec 21;206(13):3131-41
pubmed: 19995953
J Invest Dermatol. 2012 Jan;132(1):241-4
pubmed: 21900947
Cytometry B Clin Cytom. 2014 Jul;86(4):292-6
pubmed: 24115371
Haematologica. 2008 Nov;93(11):1658-65
pubmed: 18835836
Leukemia. 1999 Apr;13(4):614-7
pubmed: 10214870
Blood. 2017 Jul 20;130(3):285-296
pubmed: 28539325
Clin Exp Immunol. 2004 May;136(2):349-55
pubmed: 15086401
Genes Chromosomes Cancer. 2017 Feb;56(2):89-116
pubmed: 27636224
Haematologica. 2016 Sep;101(9):1010-7
pubmed: 27582570
N Engl J Med. 2015 Oct 15;373(16):1541-52
pubmed: 26465987
Eur J Immunol. 2017 Nov;47(11):1970-1981
pubmed: 28691750
Br J Haematol. 2015 Feb;168(3):395-404
pubmed: 25312094
J Thorac Cardiovasc Surg. 2013 Mar;145(3):656-62, 662.e1-2; discussion 662
pubmed: 23312343
Blood. 2005 Jun 1;105(11):4247-54
pubmed: 15728125
Nat Med. 2018 Jan;24(1):20-28
pubmed: 29155426
Blood. 2018 Feb 15;131(7):746-758
pubmed: 29284597
Blood Adv. 2017 Nov 21;1(25):2348-2360
pubmed: 29296885
Br J Haematol. 2014 Sep;166(6):818-29
pubmed: 24935654
Blood. 2000 Oct 1;96(7):2543-9
pubmed: 11001909
Clin Immunol Immunopathol. 1996 Dec;81(3):277-81
pubmed: 8938105
Br J Haematol. 2012 Nov;159(4):454-61
pubmed: 22994934
Blood. 2009 Dec 10;114(25):5136-45
pubmed: 19828704
Clin Exp Immunol. 2008 Dec;154(3):375-83
pubmed: 18811694
JCI Insight. 2018 Jul 12;3(13):
pubmed: 29997304
Clin Exp Immunol. 2009 Mar;155(3):523-33
pubmed: 19220838
Haematologica. 2014 Jul;99(7):1168-75
pubmed: 24727813
Genes Chromosomes Cancer. 2009 Sep;48(9):795-805
pubmed: 19530250
N Engl J Med. 2011 Nov 3;365(18):1673-83
pubmed: 22047558
Blood. 1991 Sep 1;78(5):1173-82
pubmed: 1878584
J Immunol. 2005 Jun 15;174(12):7904-11
pubmed: 15944296
Leuk Lymphoma. 1997 Jul;26(3-4):287-98
pubmed: 9322891
Blood. 2016 Apr 14;127(15):1863-9
pubmed: 26747249
Blood. 2017 Oct 26;130(17):1898-1902
pubmed: 28847997
Nature. 2013 Dec 19;504(7480):S13-5
pubmed: 24352359
Cancer Res. 2016 Apr 15;76(8):2478-89
pubmed: 26837759
Br J Haematol. 2012 Nov;159(3):299-310
pubmed: 22934889
J Exp Med. 1993 Aug 1;178(2):391-401
pubmed: 7688021
Stem Cells. 2016 Mar;34(3):581-7
pubmed: 26850912
J Leukoc Biol. 2001 May;69(5):713-8
pubmed: 11358978
Leuk Res. 1999 Jan;23(1):19-27
pubmed: 9933131
Leukemia. 2018 Sep;32(9):1970-1983
pubmed: 29483708
J Clin Invest. 2018 Jul 2;128(7):2802-2818
pubmed: 29781813
Stem Cells. 2013 Oct;31(10):2061-72
pubmed: 23836491
Leukemia. 2008 Jan;22(1):124-31
pubmed: 17928886
J Clin Invest. 2016 Mar 1;126(3):1126-36
pubmed: 26901814
J Clin Invest. 1999 Feb;103(4):453-60
pubmed: 10021452
Immunology. 2013 Sep;140(1):22-30
pubmed: 23621371