Local Gastrointestinal Injury Exacerbates Inflammation and Dopaminergic Cell Death in Parkinsonian Mice.
Neurodegeneration
Parkinson’s disease
Systemic inflammation
Ulcerative colitis
Journal
Neurotoxicity research
ISSN: 1476-3524
Titre abrégé: Neurotox Res
Pays: United States
ID NLM: 100929017
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
04
11
2018
accepted:
29
01
2019
revised:
14
01
2019
pubmed:
24
2
2019
medline:
24
5
2019
entrez:
24
2
2019
Statut:
ppublish
Résumé
The cause of progressive degeneration in Parkinson's disease is not clear, although, in the last years, different studies have suggested that both brain and peripheral inflammation could play a key role in the progression of this disorder. In our study, we aimed to analyze the effect of an acute inflammation confined to the colon on dopaminergic neuronal death and glial response in mice intoxicated with MPTP. The results obtained show a very significant decrease of dopaminergic neurons in the SNpc as well as a significant decrease of dopaminergic fibers in the striatum of the MPTP+DSS-treated group compared with the control animals. In addition, there was a significant exacerbation of microglial and astrocytes activation in MPTP+DSS animals compared with the control group. This data suggests that a specific gastrointestinal injury, which induces a systemic inflammatory response, is able to exacerbate cell death mechanisms of the remaining dopaminergic neurons and then contributes to the persistent progression of the disease. These results leave open new lines of research on the role of exclusive colonic inflammation and the progression of nigrostriatal dopaminergic degeneration.
Identifiants
pubmed: 30796691
doi: 10.1007/s12640-019-0010-z
pii: 10.1007/s12640-019-0010-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
918-930Subventions
Organisme : Fundación Séneca
ID : 19540/PI/14
Organisme : FP7 Ideas: European Research Council
ID : 115009
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