BRCA gene mutations do not shape the extent and organization of tumor infiltrating lymphocytes in triple negative breast cancer.
BRCA gene mutations
PD-1 and PD-L1
Tertiary lymphoid structures
Triple negative breast cancer
Tumor infiltrating lymphocytes
Journal
Cancer letters
ISSN: 1872-7980
Titre abrégé: Cancer Lett
Pays: Ireland
ID NLM: 7600053
Informations de publication
Date de publication:
28 05 2019
28 05 2019
Historique:
received:
19
09
2018
revised:
23
12
2018
accepted:
11
02
2019
pubmed:
25
2
2019
medline:
6
2
2020
entrez:
25
2
2019
Statut:
ppublish
Résumé
This study investigated the prevalence of TIL subpopulations, TLS, PD-1 and PD-L1 in tumors from TNBC patients harboring wild-type or mutated BRCA1 or BRCA2 germline genes. This TNBC cohort included 85% TIL-positive (≥10%) tumors with 21% classified as TIL
Identifiants
pubmed: 30797818
pii: S0304-3835(19)30105-3
doi: 10.1016/j.canlet.2019.02.027
pii:
doi:
Substances chimiques
B7-H1 Antigen
0
CD274 protein, human
0
PDCD1 protein, human
0
Programmed Cell Death 1 Receptor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
88-97Informations de copyright
Copyright © 2019. Published by Elsevier B.V.