In vitro and in vivo efficacy of an anti-CD203c conjugated antibody (AGS-16C3F) in mouse models of advanced systemic mastocytosis.
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
26 02 2019
26 02 2019
Historique:
received:
21
09
2018
accepted:
13
01
2019
entrez:
27
2
2019
pubmed:
26
2
2019
medline:
3
3
2020
Statut:
ppublish
Résumé
Antibody-drug conjugates (ADCs) are a new class of therapeutics that use antibodies to deliver potent cytotoxic drugs selectively to cancer cells. CD203c, an ecto-nucleotide pyrophosphatase-phosphodiesterase 3, is overexpressed on neoplastic mast cells (MCs) in systemic mastocytosis (SM), thus representing a promising target for antibody-mediated therapy. In this study, we have found that human neoplastic MC lines (ROSA
Identifiants
pubmed: 30804017
pii: bloodadvances.2018026179
doi: 10.1182/bloodadvances.2018026179
pmc: PMC6391676
doi:
Substances chimiques
AGS-16C3F
0
Antibodies, Monoclonal, Humanized
0
Immunoconjugates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
633-643Informations de copyright
© 2019 by The American Society of Hematology.
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