Central role of G protein Gαi2 and Gαi2
Aggression
Animals
Animals, Newborn
Biomarkers
/ metabolism
Brain
/ physiology
Brain Mapping
Female
GTP-Binding Protein alpha Subunit, Gi2
/ metabolism
Gene Deletion
Male
Mice, Inbred C57BL
Mutation
/ genetics
Sensory Receptor Cells
/ metabolism
Sexual Behavior, Animal
Territoriality
Vomeronasal Organ
/ metabolism
GCamp6f
V1R receptor
infant-directed aggression
olfactory
territorial aggression
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
12 03 2019
12 03 2019
Historique:
pubmed:
26
2
2019
medline:
7
5
2019
entrez:
27
2
2019
Statut:
ppublish
Résumé
Aggression is controlled by the olfactory system in many animal species. In male mice, territorial and infant-directed aggression are tightly regulated by the vomeronasal organ (VNO), but how diverse subsets of sensory neurons convey pheromonal information to limbic centers is not yet known. Here, we employ genetic strategies to show that mouse vomeronasal sensory neurons expressing the G protein subunit Gαi2 regulate male-male and infant-directed aggression through distinct circuit mechanisms. Conditional ablation of Gαi2 enhances male-male aggression and increases neural activity in the medial amygdala (MeA), bed nucleus of the stria terminalis, and lateral septum. By contrast, conditional Gαi2 ablation causes reduced infant-directed aggression and decreased activity in MeA neurons during male-infant interactions. Strikingly, these mice also display enhanced parental behavior and elevated neural activity in the medial preoptic area, whereas sexual behavior remains normal. These results identify Gαi2 as the primary G protein α-subunit mediating the detection of volatile chemosignals in the apical layer of the VNO, and they show that Gαi2
Identifiants
pubmed: 30804203
pii: 1821492116
doi: 10.1073/pnas.1821492116
pmc: PMC6421405
doi:
Substances chimiques
Biomarkers
0
GTP-Binding Protein alpha Subunit, Gi2
EC 3.6.5.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5135-5143Subventions
Organisme : Intramural NIH HHS
ID : Z01 ES101643
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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