Biological and clinical insights from genetics of insomnia symptoms.

Adult Aged Case-Control Studies Female Gene Expression / genetics Genetic Predisposition to Disease / genetics Humans Male Middle Aged Proteolysis Self Report Sleep / genetics Sleep Initiation and Maintenance Disorders / genetics Ubiquitin / genetics

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
03 2019
Historique:
received: 18 01 2018
accepted: 25 01 2019
pubmed: 26 2 2019
medline: 25 4 2019
entrez: 27 2 2019
Statut: ppublish

Résumé

Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.

Identifiants

DOI: 10.1038/s41588-019-0361-7 PMID: 30804566 PMC: PMC6415688
pubmed: 30804566
doi: 10.1038/s41588-019-0361-7
pii: 10.1038/s41588-019-0361-7
pmc: PMC6415688
mid: NIHMS1519714
doi:

Substances chimiques

Ubiquitin 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

387-393

Subventions

Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : R01 HG003054
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL113338
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135818
Pays : United States
Organisme : Wellcome Trust
ID : 107851/Z/15/Z
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK102696
Pays : United States
Organisme : NIDDK NIH HHS
ID : F32 DK102323
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : T32 HL007567
Pays : United States
Organisme : Medical Research Council
ID : MR/P012167/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : K01 HL136884
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107859
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL121728
Pays : United States
Organisme : Medical Research Council
ID : MR/P023576/2
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : K01 HL135405
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK105072
Pays : United States

Investigateurs

Amy E Martinsen (AE)
Anne H Skogholt (AH)
Ben Brumpton (B)
Bendik S Winsvold (BS)
Børge Sivertsen (B)
Cristen J Willer (CJ)
Daniela Bragantini (D)
Håvard Kallestad (H)
Imre Janszky (I)
Ismail C Guzey (IC)
John-Anker Zwart (JA)
Jonas B Nielsen (JB)
Kristian B Nilsen (KB)
Kristian Hveem (K)
Lars Fritsche (L)
Linda M Pedersen (LM)
Linn B Strand (LB)
Maiken E Gabrielsen (ME)
Marianne B Johnsen (MB)
Marie U Lie (MU)
Morten Engstrøm (M)
Trond Sand (T)
Wei Zhou (W)

Références

BMC Bioinformatics. 2013 Apr 15;14:128
pubmed: 23586463
Nat Genet. 2012 Mar 18;44(4):369-75, S1-3
pubmed: 22426310
Chest. 2017 Aug;152(2):435-444
pubmed: 28153671
Sleep. 2013 Jul 01;36(7):991-998
pubmed: 23814335
Nat Genet. 2017 Nov;49(11):1584-1592
pubmed: 28604731
Nature. 2016 Aug 18;536(7616):333-337
pubmed: 27487216
Lancet Neurol. 2017 Nov;16(11):898-907
pubmed: 29029846
Continuum (Minneap Minn). 2017 Aug;23(4, Sleep Neurology):1005-1016
pubmed: 28777173
Genet Epidemiol. 2013 Nov;37(7):658-65
pubmed: 24114802
Lancet Respir Med. 2015 Oct;3(10):769-81
pubmed: 26423011
Int J Epidemiol. 2013 Aug;42(4):968-77
pubmed: 22879362
Genet Epidemiol. 2016 May;40(4):304-14
pubmed: 27061298
Nat Genet. 2016 Mar;48(3):245-52
pubmed: 26854917
Ann Intern Med. 2016 Mar 1;164(5):350-9
pubmed: 26857948
Nat Genet. 2015 Mar;47(3):284-90
pubmed: 25642633
Nat Genet. 2017 Feb;49(2):274-281
pubmed: 27992416
Neuron. 2011 Dec 22;72(6):964-76
pubmed: 22196332
Indian J Psychiatry. 2013 Jul;55(3):220-3
pubmed: 24082241
PLoS One. 2013 Nov 25;8(11):e75362
pubmed: 24282498
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
Front Behav Neurosci. 2017 Mar 06;11:35
pubmed: 28321184
Nat Genet. 2015 Nov;47(11):1236-41
pubmed: 26414676
Elife. 2018 May 30;7:
pubmed: 29846171
Nature. 2016 Nov 17;539(7629):378-383
pubmed: 27806374
Br J Psychiatry. 2014 Nov;205(5):407-8
pubmed: 25061118
Nat Genet. 2016 Jul;48(7):817-20
pubmed: 27270105
Nat Genet. 2019 Mar;51(3):394-403
pubmed: 30804565
Front Psychiatry. 2015 Apr 30;6:59
pubmed: 25983695
Int J Epidemiol. 2015 Apr;44(2):512-25
pubmed: 26050253
Cold Spring Harb Perspect Biol. 2017 Aug 1;9(8):
pubmed: 28432135
Sleep Med Rev. 2017 Dec;36:71-81
pubmed: 29066053
Nat Commun. 2017 Nov 28;8(1):1826
pubmed: 29184056
Nat Genet. 2015 Nov;47(11):1228-35
pubmed: 26414678
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
Nature. 2018 Oct;562(7726):203-209
pubmed: 30305743
Bioinformatics. 2017 Jan 15;33(2):272-279
pubmed: 27663502
J Neurosci. 2000 Nov 1;20(21):8138-43
pubmed: 11050136
J Sleep Res. 2017 Dec;26(6):675-700
pubmed: 28875581
Nature. 2015 Feb 19;518(7539):337-43
pubmed: 25363779
Lancet. 2012 Mar 24;379(9821):1129-41
pubmed: 22265700
Fly (Austin). 2013 Jan-Mar;7(1):39-43
pubmed: 23455037
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
PLoS Med. 2015 Mar 31;12(3):e1001779
pubmed: 25826379
BMC Genomics. 2013 May 30;14:362
pubmed: 23721503
Nature. 2017 May 25;545(7655):477-481
pubmed: 28514446
Front Neuroanat. 2010 Nov 23;4:145
pubmed: 21151379
Nat Rev Neurosci. 2009 Aug;10(8):549-60
pubmed: 19617891
Nat Rev Dis Primers. 2015 Sep 03;1:15026
pubmed: 27189779
Nat Genet. 2016 Jul;48(7):803-10
pubmed: 27182969
PLoS Comput Biol. 2016 Jan 25;12(1):e1004714
pubmed: 26808494
J Clin Sleep Med. 2017 Feb 15;13(2):307-349
pubmed: 27998379
Hum Mol Genet. 2015 Oct 15;24(R1):R102-10
pubmed: 26152199
Brain Sci. 2016 Dec 20;6(4):
pubmed: 27999387
Sleep. 2011 Nov 01;34(11):1487-92
pubmed: 22043119
Nature. 2018 Oct;562(7726):210-216
pubmed: 30305740

Auteurs

Jacqueline M Lane (JM)

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Broad Institute, Cambridge, MA, USA.

Samuel E Jones (SE)

Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
ORCID: 0000-0003-0153-922X

Hassan S Dashti (HS)

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Broad Institute, Cambridge, MA, USA.
ORCID: 0000-0002-1650-679X

Andrew R Wood (AR)

Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.

Krishna G Aragam (KG)

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Broad Institute, Cambridge, MA, USA.
Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.

Vincent T van Hees (VT)

Netherlands eScience Center, Amsterdam, the Netherlands.
ORCID: 0000-0003-0182-9008

Linn B Strand (LB)

K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Bendik S Winsvold (BS)

K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
FORMI and Department of Neurology, Oslo University Hospital, Oslo, Norway.
Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway.
ORCID: 0000-0003-4171-8919

Heming Wang (H)

Broad Institute, Cambridge, MA, USA.
Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-1486-7495

Jack Bowden (J)

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Yanwei Song (Y)

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Broad Institute, Cambridge, MA, USA.
College of Science, Northeastern University, Boston, MA, USA.

Krunal Patel (K)

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
College of Science, Northeastern University, Boston, MA, USA.

Simon G Anderson (SG)

Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Farr Institute of Health Informatics Research, University College London, London, UK.
ORCID: 0000-0002-8896-073X

Robin N Beaumont (RN)

Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.

David A Bechtold (DA)

Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
ORCID: 0000-0001-8676-8704

Brian E Cade (BE)

Broad Institute, Cambridge, MA, USA.
Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA.

Mary Haas (M)

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Broad Institute, Cambridge, MA, USA.

Sekar Kathiresan (S)

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Broad Institute, Cambridge, MA, USA.
Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
ORCID: 0000-0002-6724-032X

Max A Little (MA)

Department of Mathematics, Aston University, Birmingham, UK.
Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.

Annemarie I Luik (AI)

Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Andrew S Loudon (AS)

Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Shaun Purcell (S)

Department of Psychiatry, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

Rebecca C Richmond (RC)

School of Social and Community Medicine, University of Bristol, Bristol, UK.
Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
ORCID: 0000-0003-0574-5071

Frank A J L Scheer (FAJL)

Broad Institute, Cambridge, MA, USA.
Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA.

Barbara Schormair (B)

Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Jessica Tyrrell (J)

Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.

John W Winkelman (JW)

Departments of Psychiatry and Neurology, Massachusetts General Hospital, Boston, MA, USA.

Juliane Winkelmann (J)

Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Cluster for Systems Neurology (SyNergy), Munich, Germany.
Institute of Human Genetics, Technische Universität München, Munich, Germany.
Neurogenetics, Technische Universität München, Munich, Germany.

Kristian Hveem (K)

K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Chen Zhao (C)

Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Jonas B Nielsen (JB)

FORMI and Department of Neurology, Oslo University Hospital, Oslo, Norway.
ORCID: 0000-0002-6654-2852

Cristen J Willer (CJ)

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0001-5645-4966

Susan Redline (S)

Departments of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Kai Spiegelhalder (K)

Clinic for Psychiatry and Psychotherapy, Medical Centre-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Simon D Kyle (SD)

Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

David W Ray (DW)

Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE/NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK.
ORCID: 0000-0002-4739-6773

John-Anker Zwart (JA)

K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway.

Ben Brumpton (B)

K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Department of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.

Timothy M Frayling (TM)

Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.

Deborah A Lawlor (DA)

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-6793-2262

Martin K Rutter (MK)

Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

Michael N Weedon (MN)

Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK.

Richa Saxena (R)

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. rsaxena@partners.org.
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. rsaxena@partners.org.
Broad Institute, Cambridge, MA, USA. rsaxena@partners.org.
ORCID: 0000-0003-2233-1065

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questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Biological and clinical insights from genetics...
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