Impaired voice processing in reward and salience circuits predicts social communication in children with autism.
auditory
autism
brain
human
mother
neuroscience
reward
voice
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
26 02 2019
26 02 2019
Historique:
received:
07
07
2018
accepted:
29
01
2019
entrez:
27
2
2019
pubmed:
27
2
2019
medline:
25
3
2020
Statut:
epublish
Résumé
Engaging with vocal sounds is critical for children's social-emotional learning, and children with autism spectrum disorder (ASD) often 'tune out' voices in their environment. Little is known regarding the neurobiological basis of voice processing and its link to social impairments in ASD. Here, we perform the first comprehensive brain network analysis of voice processing in children with ASD. We examined neural responses elicited by unfamiliar voices and mother's voice, a biologically salient voice for social learning, and identified a striking relationship between social communication abilities in children with ASD and activation in key structures of reward and salience processing regions. Functional connectivity between voice-selective and reward regions during voice processing predicted social communication in children with ASD and distinguished them from typically developing children. Results support the Social Motivation Theory of ASD by showing reward system deficits associated with the processing of a critical social stimulus, mother's voice, in children with ASD. This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that minor issues remain unresolved (see decision letter).
Identifiants
pubmed: 30806350
doi: 10.7554/eLife.39906
pii: 39906
pmc: PMC6391069
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : MH084164
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH102428
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH084164
Pays : United States
Organisme : Brain and Behavior Research Foundation
ID : NARSAD Young Investigator Grant
Pays : International
Organisme : NIDCD NIH HHS
ID : DC011095
Pays : United States
Organisme : NIMH NIH HHS
ID : MH102428
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1TR001085
Pays : United States
Organisme : NIDCD NIH HHS
ID : R21 DC011095
Pays : United States
Organisme : Stanford School of Medicine, Stanford Medicine, Stanford University
ID : UL1TR001085
Pays : International
Organisme : NCATS NIH HHS
ID : UL1 TR003142
Pays : United States
Organisme : Simons Foundation
ID : 308939
Pays : International
Organisme : NCATS NIH HHS
ID : UL1 TR001085
Pays : United States
Informations de copyright
© 2019, Abrams et al.
Déclaration de conflit d'intérêts
DA, AP, TC, PO, AB, JK, JP, VM No competing interests declared
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