Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children.
Antiretroviral Therapy, Highly Active
Biomarkers
CD4 Lymphocyte Count
Disease Progression
HIV Infections
/ drug therapy
HIV-1
/ immunology
Homeostasis
Humans
Immunologic Memory
Lymphocyte Activation
/ immunology
Signal Transduction
T-Lymphocyte Subsets
/ immunology
T-Lymphocytes, Regulatory
/ immunology
Viral Load
homeostatic signaling
IL-10
IL-7
immune activation (IA)
immune regulation
pediatric HIV-infection
pediatric slow progression
regulatory T cells (Treg)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
10
2018
accepted:
24
01
2019
entrez:
28
2
2019
pubmed:
28
2
2019
medline:
17
1
2020
Statut:
epublish
Résumé
Pediatric slow progressors (PSP) are rare ART-naïve, HIV-infected children who maintain high CD4 T-cell counts and low immune activation despite persistently high viral loads. Using a well-defined cohort of PSP, we investigated the role of regulatory T-cells (T
Identifiants
pubmed: 30809229
doi: 10.3389/fimmu.2019.00213
pmc: PMC6379343
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
213Subventions
Organisme : NIAID NIH HHS
ID : R01 AI133673
Pays : United States
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