Sonographic findings from inflammatory arthritis due to antisynthetase syndrome.
Antisynthetase syndrome
Inflammatory arthritis
Inflammatory myopathy
Ultrasonography
Journal
Clinical rheumatology
ISSN: 1434-9949
Titre abrégé: Clin Rheumatol
Pays: Germany
ID NLM: 8211469
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
16
01
2019
accepted:
06
02
2019
revised:
29
01
2019
pubmed:
28
2
2019
medline:
4
12
2019
entrez:
28
2
2019
Statut:
ppublish
Résumé
Inflammatory arthritis is a common feature of antisynthetase syndrome. Ultrasonography is able to characterize important features of bone and tendon pathology but has not been evaluated in this setting. We review the sonographic findings in a series of patients with antisynthetase syndrome and inflammatory arthritis. A retrospective chart review was performed of patients with antisynthetase syndrome-associated inflammatory arthritis who had undergone ultrasound imaging for joint pathology. Seventeen sonographic assessments of eight patients were included. Synovial hypertrophy was seen in all eight patients, with active Doppler signal present in six patients (13 of 17 ultrasound locations). Tendon involvement was common, with tenosynovitis in seven patients (11 of 17 ultrasound locations). Erosions were present in five patients. Musculoskeletal ultrasound showed significant joint pathology including proliferative synovitis and tenosynovitis. This may be severe and associated with erosive disease. Further systematic studies are needed to better understand the articular involvement of antisynthetase syndrome. Key points • Marked inflammatory change-with proliferative synovitis, tenosynovitis, and erosions-can be seen in selected patients with antisynthetase syndrome (ASyS). • Inflammatory arthritis from ASyS can be severe and erosive in the absence of RF and ACPA and can be refractory to immunosuppressive therapy used to manage the myositis and interstitial lung disease. • Systematic sonographic evaluation of patients with ASyS is needed to further evaluate pathology and treatment response of inflammatory arthritis.
Identifiants
pubmed: 30810913
doi: 10.1007/s10067-019-04471-y
pii: 10.1007/s10067-019-04471-y
pmc: PMC6541484
mid: NIHMS1026225
doi:
Substances chimiques
Autoantibodies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1477-1483Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR070254
Pays : United States
Références
Mahler M, Miller FW, Fritzler MJ (2014) Idiopathic inflammatory myopathies and the anti-synthetase syndrome: a comprehensive review. Autoimmun Rev 13:367–371. https://doi.org/10.1016/j.autrev.2014.01.022
doi: 10.1016/j.autrev.2014.01.022
pubmed: 24424190
pmcid: 3970575
Gonzalez-Gay MA, Montecucco C, Selva-O’Callaghan A, Trallero-Araguas E, Molberg O, Andersson H et al (2018) Timing of onset affects arthritis presentation pattern in antisyntethase syndrome. Clin Exp Rheumatol 36:44–49
pubmed: 28770709
Cavagna L, Nuño L, Scirè CA, Govoni M, Longo FJL, Franceschini F, Neri R, Castañeda S, Giraldo WAS, Caporali R, Iannone F, Fusaro E, Paolazzi G, Pellerito R, Schwarting A, Saketkoo LA, Ortego-Centeno N, Quartuccio L, Bartoloni E, Specker C, Murcia TP, la Corte R, Furini F, Foschi V, Corral JB, Airò P, Cavazzana I, Martínez-Barrio J, Hinojosa M, Giannini M, Barsotti S, Menke J, Triantafyllias K, Vitetta R, Russo A, Bajocchi G, Bravi E, Barausse G, Bortolotti R, Selmi C, Parisi S, Montecucco C, González-Gay MA (2015) Clinical spectrum time course in anti Jo-1 positive antisynthetase syndrome. Medicine (Baltimore) 94:e1144. https://doi.org/10.1097/MD.0000000000001144
doi: 10.1097/MD.0000000000001144
Cavagna L, Nuño L, Scirè CA et al (2017) Serum Jo-1 autoantibody and isolated arthritis in the antisynthetase syndrome: review of the literature and report of the experience of AENEAS collaborative group. Clin Rev Allergy Immunol 52:71–80. https://doi.org/10.1007/s12016-016-8528-9
doi: 10.1007/s12016-016-8528-9
pubmed: 26782036
Lefèvre G, Meyer A, Launay D, Machelart I, DeBandt M, Michaud J, Tournadre A, Godmer P, Kahn JE, Behra-Marsac A, Timsit MA, Schleinitz N, Wendling D, Melac-Ducamp S, Boyer P, Peretz A, Lequerré T, Richez C, Stervinou-Wemeau L, Morell-Dubois S, Lambert M, Dubucquoi S, Wallaert B, Benveniste O, Flipo RM, Hatron PY, Sibilia J, Hachulla E, Hervier B, Club Rhumatismes, Inflammation (2015) Seronegative polyarthritis revealing antisynthetase syndrome: a multicentre study of 40 patients. Rheumatol (United Kingdom) 54:927–932. https://doi.org/10.1093/rheumatology/keu404
doi: 10.1093/rheumatology/keu404
Nagashima T, Iwamoto M, Minota S (2011) Antisynthetase syndrome associated with long-standing rheumatoid arthritis. Rheumatol Int 31:705–706. https://doi.org/10.1007/s00296-010-1467-5
doi: 10.1007/s00296-010-1467-5
pubmed: 20352218
Ide V, Bossuyt X, Blockmans D, De Langhe E (2018) Prevalence and clinical correlates of rheumatoid factor and anticitrullinated protein antibodies in patients with idiopathic inflammatory myopathy. RMD Open 4:1–7. https://doi.org/10.1136/rmdopen-2018-000661
doi: 10.1136/rmdopen-2018-000661
Labrador-Horrillo M, Martinez MA, Selva-O’Callaghan A et al (2009) Anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with idiopathic inflammatory myopathy. Rheumatology 48:676–679. https://doi.org/10.1093/rheumatology/kep065
doi: 10.1093/rheumatology/kep065
pubmed: 19386818
Meyer A, Lefevre G, Bierry G, Duval A, Ottaviani S, Meyer O, Tournadre A, le Goff B, Messer L, Buchdahl AL, de Bandt M, Deligny C, Dubois M, Coquerelle P, Falgarone G, Flipo RM, Mathian A, Geny B, Amoura Z, Benveniste O, Hachulla E, Sibilia J, Hervier B, Club Rhumatismes et Inflammation (2015) In antisynthetase syndrome, ACPA are associated with severe and erosive arthritis: an overlapping rheumatoid arthritis and antisynthetase syndrome. Medicine 94:e523. https://doi.org/10.1016/S1470-2045(06)70623-4
doi: 10.1097/MD.0000000000000523
pubmed: 25997035
pmcid: 4602869
Nagashima T, Sato H, Minota S (2009) Destructive arthropathy associated with dermatomyositis sine myositis positive for anti-Jo-1 and anti-cyclic citrullinated peptide antibodies. J Rheumatol 36:2133–2134. https://doi.org/10.1016/j.cej.2017.05.115
doi: 10.3899/jrheum.090183
pubmed: 19738232
Colebatch AN, Edwards CJ, Østergaard M, van der Heijde D, Balint PV, D'Agostino MA, Forslind K, Grassi W, Haavardsholm EA, Haugeberg G, Jurik AG, Landewé RBM, Naredo E, O'Connor PJ, Ostendorf B, Potočki K, Schmidt WA, Smolen JS, Sokolovic S, Watt I, Conaghan PG (2013) EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis. Ann Rheum Dis 72:804–814. https://doi.org/10.1136/annrheumdis-2012-203158
doi: 10.1136/annrheumdis-2012-203158
Forien M, Ottaviani S (2016) Ultrasound and follow-up of rheumatoid arthritis. Jt Bone Spine 84:531–536. https://doi.org/10.1016/j.jbspin.2016.08.003
doi: 10.1016/j.jbspin.2016.08.003
Filer A, De Pablo P, Allen G et al (2011) Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitis. Ann Rheum Dis 70:500–507. https://doi.org/10.1136/ard.2010.131573
doi: 10.1136/ard.2010.131573
pubmed: 21115552
Kelly S, Bombardieri M, Humby F, Ng N, Marrelli A, Riahi S, DiCicco M, Mahto A, Zou L, Pyne D, Hands RE, Pitzalis C (2015) Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: an observational study. Arthritis Res Ther 17:58. https://doi.org/10.1186/s13075-015-0567-8
doi: 10.1186/s13075-015-0567-8
pubmed: 25889955
pmcid: 4476089
Wakefield RJ, Balint PV, Szkudlarek M, Filippucci E, Backhaus M, D'Agostino MA, Sanchez EN, Iagnocco A, Schmidt WA, Bruyn GA, Kane D, O'Connor PJ, Manger B, Joshua F, Koski J, Grassi W, Lassere MN, Swen N, Kainberger F, Klauser A, Ostergaard M, Brown AK, Machold KP, Conaghan PG, OMERACT 7 Special Interest Group (2005) Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol 32:2485–2487
pubmed: 16331793
Niemantsverdriet E, van der Helm-van Mil AHM (2018) Imaging detected tenosynovitis of metacarpophalangeal and wrist joints: an increasingly recognised characteristic of rheumatoid arthritis. Clin Exp Rheumatol 36:131–138
pubmed: 30296973
Eshed I, Feist E, Althoff CE, Hamm B, Konen E, Burmester GR, Backhaus M, Hermann KGA (2009) Tenosynovitis of the flexor tendons of the hand detected by MRI: an early indicator of rheumatoid arthritis. Rheumatology 48:887–891. https://doi.org/10.1093/rheumatology/kep136
doi: 10.1093/rheumatology/kep136
pubmed: 19474128
Emad Y, Ragab Y, Abd-Elsalam M, Rasker JJ (2018) Antisynthetase syndrome complicating the course of established case with rheumatoid arthritis: a rare and under-recognized overlapping disease. Reumatol Clin. https://doi.org/10.1016/j.reuma.2018.06.002
Ishikawa Y, Yukawa N, Kawabata D, Ohmura K, Fujii T, Usui T, Mimori T (2011) A case of antisynthetase syndrome in a rheumatoid arthritis patient with anti-PL-12 antibody following treatment with etanercept. Clin Rheumatol 30:429–432. https://doi.org/10.1007/s10067-010-1666-1
doi: 10.1007/s10067-010-1666-1
pubmed: 21221686
Park CK, Kim TJ, Cho YN, Kim IS, Lee HJ, Lee KE, Park SC, Kim JS, Park DJ, Lee SJ, Seo SR, Kim JC, Song SG, Lee SS, Park YW (2011) Development of antisynthetase syndrome in a patient with rheumatoid arthritis. Rheumatol Int 31:529–532. https://doi.org/10.1007/s00296-009-1222-y
doi: 10.1007/s00296-009-1222-y
pubmed: 19847427
Wendling D, Golden C, Monet M, Verhoeven F, Guillot X, Prati C (2016) Rheumatoid arthritis and antisynthetase syndrome. A three cases report. Jt Bone Spine 83:739–740. https://doi.org/10.1016/j.jbspin.2015.10.014
doi: 10.1016/j.jbspin.2015.10.014
Cavagna L, Fusetti C, Montecucco C, Caporali R (2010) Anticyclic citrullinated peptide antibodies as markers of erosive arthritis in antisynthetase syndrome. J Rheumatol 37:1967. https://doi.org/10.3899/jrheum.091402
doi: 10.3899/jrheum.091402
pubmed: 20810525
La Corte R, Lo Mo Naco A, Locaputo A et al (2006) In patients with antisynthetase syndrome the occurrence of anti-Ro/SSA antibodies causes a more severe interstitial lung disease. Autoimmunity 39:249–253. https://doi.org/10.1080/08916930600623791
doi: 10.1080/08916930600623791
pubmed: 16769659
Marie I, Hatron PY, Dominique S, Cherin P, Mouthon L, Menard JF, Levesque H, Jouen F (2012) Short-term and long-term outcome of anti-Jo1-positive patients with anti-Ro52 antibody. Semin Arthritis Rheum 41:890–899. https://doi.org/10.1016/j.semarthrit.2011.09.008
doi: 10.1016/j.semarthrit.2011.09.008
pubmed: 22078416
Pinal-Fernandez I, Casal-Dominguez M, Huapaya JA, Albayda J, Paik JJ, Johnson C, Silhan L, Christopher-Stine L, Mammen AL, Danoff SK (2017) A longitudinal cohort study of the anti-synthetase syndrome: increased severity of interstitial lung disease in black patients and patients with anti-PL7 and anti-PL12 autoantibodies. Rheumatology (United Kingdom) 56:999–1007. https://doi.org/10.1093/rheumatology/kex021
doi: 10.1093/rheumatology/kex021