Camptothecin encapsulated into functionalized MCM-41: In vitro release study, cytotoxicity and kinetics.
12-tungstophosphoric acid
Camptothecin
In vitro release
Kinetics
MCM-41
MTT assay
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
22
06
2018
revised:
04
01
2019
accepted:
15
01
2019
entrez:
1
3
2019
pubmed:
1
3
2019
medline:
25
6
2019
Statut:
ppublish
Résumé
The application of MCM-41 functionalized by 12-tungstophosphoric acid (TPA) as drug carrier for cancer treatment was studied by loading of camptothecin (CPT). In-vitro controlled release study of CPT in Simulated Body Fluid (pH 7.4, 37 °C) was carried out under stirring as well as static conditions. The systems were also evaluated on cancer cells (HepG2) and the carriers are found to be non-toxic to the cancer cells. In order to see the influence of inorganic moiety on release rate of drug, study was also carried out with CPT loaded unfunctionalized MCM-41. A detailed study on release kinetics and release mechanism using First Order Release Kinetic Model, Higuchi Model, Koresmeyer-Pepps Model and Extended kinetic model was also carried out.
Identifiants
pubmed: 30812985
pii: S0928-4931(18)31774-0
doi: 10.1016/j.msec.2019.01.065
pii:
doi:
Substances chimiques
MCM-41
0
Silicon Dioxide
7631-86-9
Camptothecin
XT3Z54Z28A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1014-1021Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.