Breast cancer cells rely on environmental pyruvate to shape the metastatic niche.
Animals
Breast Neoplasms
/ enzymology
Cell Line, Tumor
Collagen
/ chemistry
Disease Models, Animal
Enzyme Activation
/ drug effects
Extracellular Matrix
/ drug effects
Female
Humans
Hydroxylation
/ drug effects
Ketoglutaric Acids
/ metabolism
Lung Neoplasms
/ metabolism
Mice
Neoplasm Metastasis
/ pathology
Procollagen-Proline Dioxygenase
/ metabolism
Pyruvic Acid
/ metabolism
Tumor Microenvironment
/ drug effects
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
01
11
2017
accepted:
28
01
2019
pubmed:
1
3
2019
medline:
20
8
2019
entrez:
1
3
2019
Statut:
ppublish
Résumé
The extracellular matrix is a major component of the local environment-that is, the niche-that determines cell behaviour
Identifiants
pubmed: 30814728
doi: 10.1038/s41586-019-0977-x
pii: 10.1038/s41586-019-0977-x
pmc: PMC6451642
mid: EMS81520
doi:
Substances chimiques
Ketoglutaric Acids
0
Pyruvic Acid
8558G7RUTR
Collagen
9007-34-5
Procollagen-Proline Dioxygenase
EC 1.14.11.2
Types de publication
Journal Article
Langues
eng
Pagination
117-121Commentaires et corrections
Type : CommentIn
Références
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