Controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood.
Age Factors
Animals
Behavior, Animal
/ physiology
Choice Behavior
/ physiology
Cognition
/ physiology
Corpus Striatum
/ physiology
Delay Discounting
/ physiology
Endocrine System
/ physiology
Humans
Impulsive Behavior
/ physiology
Male
Rats
Reaction Time
/ physiology
Receptors, Dopamine D2
/ metabolism
Stress, Psychological
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 02 2019
28 02 2019
Historique:
received:
18
06
2018
accepted:
01
02
2019
entrez:
1
3
2019
pubmed:
1
3
2019
medline:
17
9
2020
Statut:
epublish
Résumé
Exposure to stress during adolescence exerts a long-term impact on behavior and might contribute to the development of several neuropsychiatric disorders. In adults, control over stress has been found to protect from the negative consequences of stress, but the influence of controllability at early ages has not been extensively studied. Here, we evaluated in a rodent model the effects of repeated exposure in adolescent male rats to controllable versus uncontrollable foot-shock stress (CST or UST, respectively). Rats were assigned to three groups: non-stress (stress-naïve), CST (exposed to 8 sessions of a two-way shuttle active avoidance task over a period of 22 days) and UST (receiving the same amount of shocks as CST, regardless of their actual behavior). During adulthood, different cohorts were tested in several tasks evaluating inhibitory control and cognitive flexibility: 5-choice serial reaction time, delay-discounting, gambling test and probabilistic reversal learning. Results showed that the hypothalamic-pituitary-adrenal response to the first shock session was similar in CST and UST animals, but the response to the 8
Identifiants
pubmed: 30816288
doi: 10.1038/s41598-019-40061-3
pii: 10.1038/s41598-019-40061-3
pmc: PMC6395608
doi:
Substances chimiques
Receptors, Dopamine D2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3180Références
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